BACKGROUND Magnetic resonance (MR) black-blood thrombus imaging (BTI) is an accurate diagnostic technique for detecting deep vein thrombosis (DVT) but to date there have been no studies comparing the diagnostic performance and consistency of this technique at different field strengths. In this study, we evaluated and compared the diagnostic performance of BTI for detecting DVT at 1.5 T and 3.0 T field strengths. METHODS A total of 40 patients with DVT were enrolled in this study from November 2015 up to October 2018. All patients underwent BTI, a contrast-free T1-weighted MR imaging technique for detecting DVT, and contrast-enhanced MR venography (CE-MRV) at 1.5 T or 3.0 T field strengths. The MR data analyses used 1160 segments from the venous lumen of the 40 patients. The signal-to-noise ratio and contrast-to-noise ratio between thrombus and muscle/lumen were calculated to compare BTI at 1.5 T or 3.0 T to determine the image performance for thrombus detection at 1.5 T or 3.0 T. Two physicians blinded to the study evaluated all BTI images and calculated the overall sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV), accuracy, and diagnostic consistency at 1.5 T and 3.0 T. These images and values were compared to control CE-MRV images that had been obtained by 2 senior physicians and used as reference standards. In addition, the reliability and consistency of diagnoses between observers were also evaluated. RESULTS Two study-blind physicians reviewed all BTI images to diagnose thrombus and to determine SE, SP, PPV, NPV, and accuracy. There were no statistical differences in SE, SP, PPV, NPV, or accuracy between the 1.5 T and 3.0 T groups. CONCLUSIONS Black-blood thrombus imaging has high SE, SP, and accuracy for DVT diagnosis both at 1.5 T and 3.0 T field strengths. This noninvasive diagnostic technique, which does not require the use of contrast agents, can be widely used in the clinical screening of DVT and follow-up after treatment.

中文翻译：

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使用磁共振黑血血栓成像检测深静脉血栓形成的 1.5 T 和 3.0 T 场强的诊断性能比较。

背景技术磁共振 (MR) 黑血血栓成像 (BTI) 是一种用于检测深静脉血栓形成 (DVT) 的准确诊断技术，但迄今为止还没有研究比较该技术在不同场强下的诊断性能和一致性。在这项研究中，我们评估并比较了 BTI 在 1.5 T 和 3.0 T 场强下检测 DVT 的诊断性能。方法 从 2015 年 11 月至 2018 年 10 月，共有 40 名 DVT 患者参加了本研究。所有患者均接受了 BTI，一种用于检测 DVT 的无对比 T1 加权 MR 成像技术，以及对比增强 MR 静脉造影（CE-MRV ) 在 1.5 T 或 3.0 T 场强下。MR 数据分析使用了 40 名患者的静脉管腔中的 1160 个节段。计算血栓和肌肉/管腔之间的信噪比和对比噪声比，以比较 1.5 T 或 3.0 T 下的 BTI，以确定 1.5 T 或 3.0 T 下血栓检测的图像性能。该研究评估了所有 BTI 图像，并计算了 1.5 T 和 3.0 T 下的总体敏感性 (SE)、特异性 (SP)、阳性预测值 (PPV) 和阴性预测值 (NPV)、准确性和诊断一致性。这些图像和值与由 2 位资深医师获得并用作参考标准的对照 CE-MRV 图像进行比较。此外，还评估了观察者之间诊断的可靠性和一致性。结果 两位研究盲的医生审查了所有 BTI 图像以诊断血栓并确定 SE、SP、PPV、NPV 和准确性。1.5 T 和 3.0 T 组之间的 SE、SP、PPV、NPV 或准确性没有统计学差异。结论 黑血血栓成像在 1.5 T 和 3.0 T 场强下均具有较高的 SE、SP 和 DVT 诊断准确性。这种无需使用造影剂的无创诊断技术，可广泛用于深静脉血栓的临床筛查和治疗后的随访。