The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, including bacteria, fungi, and viruses. As our understanding of the relationship between the oral microbiome and human health has evolved, we have identified a diverse array of oral and systemic diseases associated with this microbial community, including but not limited to caries, periodontal diseases, oral cancer, colorectal cancer, pancreatic cancer, and inflammatory bowel syndrome. The potential predictive relationship between the oral microbiota and these human diseases suggests that the oral cavity is an ideal site for disease diagnosis and development of rapid point-of-care tests. The oral cavity is easily accessible with a non-invasive collection of biological samples. We can envision a future where early life salivary diagnostic tools will be used to predict and prevent future disease via analyzing and shaping the infant's oral microbiome. In this review, we present evidence for the establishment of the oral microbiome during early childhood, the capability of using childhood oral microbiome to predict future oral and systemic diseases, and the limitations of the current evidence.

中文翻译：

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口腔微生物组：可能是儿童健康的先兆。

人类微生物组起着复杂而协调的微生物网络的作用，遍及皮肤，口腔，胃肠道，呼吸道和生殖系统的整个粘膜表面。口腔微生物组涵盖了高度多样化的微生物群，由700多种微生物组成，包括细菌，真菌和病毒。随着我们对口腔微生物组与人类健康之间关系的理解的发展，我们发现了与该微生物群落有关的多种口腔和全身性疾病，包括但不限于龋齿，牙周疾病，口腔癌，结肠直肠癌，胰腺癌癌症和炎症性肠综合症。口腔微生物群与这些人类疾病之间的潜在预测关系表明，口腔是疾病诊断和快速即时检验的发展的理想场所。通过非侵入性收集生物样品可以轻松进入口腔。我们可以预见未来将使用早期唾液诊断工具通过分析和塑造婴儿的口腔微生物组来预测和预防未来疾病。在这篇综述中，我们为幼儿期口腔微生物组的建立，使用儿童期口腔微生物组预测未来口腔和全身性疾病的能力以及当前证据的局限性提供证据。通过非侵入性收集生物样品可以轻松进入口腔。我们可以预见未来将使用早期唾液诊断工具通过分析和塑造婴儿的口腔微生物组来预测和预防未来疾病。在这篇综述中，我们为幼儿期口腔微生物组的建立，使用儿童期口腔微生物组预测未来口腔和全身性疾病的能力以及当前证据的局限性提供证据。通过非侵入性收集生物样品可以轻松进入口腔。我们可以预见未来将使用早期唾液诊断工具通过分析和塑造婴儿的口腔微生物组来预测和预防未来疾病。在这篇综述中，我们为幼儿期口腔微生物组的建立，使用儿童期口腔微生物组预测未来口腔和全身性疾病的能力以及当前证据的局限性提供证据。