Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to generate fluid flow across epithelial surfaces or turbulence to promote the transport of gametes. The MCC differentiation program is initiated by GEMC1 and MCIDAS, members of the geminin family, that activate key transcription factors, including p73 and FOXJ1, to control the multiciliogenesis program. To support the generation of multiple motile cilia, MCCs must undergo massive centriole amplification to generate a sufficient number of basal bodies (modified centrioles). This transcriptional program involves the generation of deuterosomes, unique structures that act as platforms to regulate centriole amplification, the reactivation of cell cycle programs to control centriole amplification and release, and extensive remodeling of the cytoskeleton. This review will focus on providing an overview of the transcriptional regulation of MCCs and its connection to key processes, in addition to highlighting exciting recent developments and open questions in the field.

多纤毛细胞 (MCC) 从细胞表面投射出数十到数百个活动纤毛，以产生穿过上皮表面的流体流动或湍流以促进配子的运输。MCC 分化程序由孪蛋白家族成员 GEMC1 和 MCIDAS 启动，它们激活关键转录因子，包括 p73 和 FOXJ1，以控制多纤毛发生程序。为了支持多运动纤毛的产生，MCC 必须经历大量的中心粒放大以产生足够数量的基体（修饰的中心粒）。该转录程序涉及氘核体的产生，作为调节中心粒放大的平台的独特结构，重新激活细胞周期程序以控制中心粒放大和释放，以及细胞骨架的广泛重塑。