Resveratrol (RSV) is one kind of polyphenol that possesses anti-inflammatory effect. The effect of RSV in allergic rhinitis (AR) remains unclear. In this study, we investigated the protective effect of RSV against AR and explored the related signaling pathways. AR mouse model was successfully established by intraperitoneal injection with Ovalbumin (OVA). RSV administration was performed in a diet with different doses (5, 30, 50 mg/kg). Allergic symptoms were indicated by sneezing and nasal rubbing. Cytokines in serum and nasal lavage fluid (NLF) were determined by ELISA. mRNA and protein levels were detected by RT-PCR and Western blot. Our results show that RSV treatment attenuated sneezing and nasal rubbing in AR mice. It decreased histamine release, OVA-specific IgE, IgG1, IL-4 and LTC4, inflammatory cell numbers (leucocytes, eosinophils, lymphocytes, and neutrophils), and inflammatory cytokines secretion (TNF-α, IL-6, IL-10, IL-5, IL-13, and IL-17). Mechanically, RSV treatment suppressed HMGB1 and TLR4 expression and promoted SIRT1 expression in the nasal mucosa. In conclusion, RSV is able to attenuate OVA-induced AR in mice.

中文翻译：

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白藜芦醇介导的 SIRT1 激活可减轻卵清蛋白诱导的小鼠过敏性鼻炎。


白藜芦醇（RSV）是一种具有抗炎作用的多酚。 RSV 对过敏性鼻炎 (AR) 的影响仍不清楚。在本研究中，我们研究了RSV对AR的保护作用，并探讨了相关的信号通路。通过腹腔注射卵清蛋白（OVA）成功建立AR小鼠模型。在不同剂量（5、30、50mg/kg）的饮食中进行RSV给药。打喷嚏和揉鼻表示过敏症状。通过 ELISA 测定血清和鼻灌洗液 (NLF) 中的细胞因子。通过RT-PCR和Western blot检测mRNA和蛋白水平。我们的结果表明，RSV 治疗可减轻 AR 小鼠的打喷嚏和擦鼻症状。它减少了组胺释放、OVA 特异性 IgE、IgG1、IL-4 和 LTC4、炎症细胞数量（白细胞、嗜酸性粒细胞、淋巴细胞和中性粒细胞）以及炎症细胞因子分泌（TNF-α、IL-6、IL-10、IL）。 -5、IL-13 和 IL-17）。从机械角度来看，RSV 治疗抑制了鼻粘膜中 HMGB1 和 TLR4 的表达，并促进了 SIRT1 的表达。总之，RSV 能够减弱 OVA 诱导的小鼠 AR。