OBJECTIVE Depression is widely acknowledged as the most common comorbidity of temporal lobe epilepsy (TLE), and executive control (EC) may be particularly impaired in patients with TLE with comorbid depression. The purpose of this study was to investigate brain network alterations in patients with TLE with or without depression using scalp electroencephalography (EEG), and to explore the potential mechanisms of TLE with comorbid depression. METHODS Forty patients with TLE and 20 healthy controls (HC) were recruited for administered the BDI-II and HAMD-17 surveys. The patients with TLE were divided into those with depression (PDS, n = 20) and those without depression (nPDS, n = 20) according to the surveys. Neural oscillations and functional connectivity during performance of EC tasks were calculated during EEG. RESULTS Theta oscillation and functional connectivity were significantly weakened in the PDS group compared to the nPDS and HC groups. Furthermore, the PDS group showed more serious EC dysfunction than nPDS group. CONCLUSIONS Our results indicated that weakened theta oscillation and functional connectivity in the frontal lobe may be a mechanism of EC dysfunction in TLE with comorbid depression. SIGNIFICANCE The present results suggest that the alterations in frontal lobe connections may help predict the depression in patients with TLE.

中文翻译：

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颞叶癫痫伴抑郁症与执行控制相关的 Theta 振荡和功能连接改变

目的 抑郁症被广泛认为是颞叶癫痫 (TLE) 最常见的合并症，并且在患有合并抑郁症的 TLE 患者中，执行控制 (EC) 可能尤其受损。本研究的目的是使用头皮脑电图 (EEG) 调查伴或不伴抑郁的 TLE 患者的脑网络变化，并探讨 TLE 合并抑郁症的潜在机制。方法 招募了 40 名 TLE 患者和 20 名健康对照 (HC) 进行 BDI-II 和 HAMD-17 调查。根据调查结果将TLE患者分为抑郁症（PDS，n=20）和非抑郁症（nPDS，n=20）。在 EEG 期间计算执行 EC 任务期间的神经振荡和功能连接。结果 与 nPDS 和 HC 组相比，PDS 组的 Theta 振荡和功能连接显着减弱。此外，PDS 组表现出比 nPDS 组更严重的 EC 功能障碍。结论 我们的结果表明，额叶中减弱的θ振荡和功能连接可能是 TLE 合并抑郁症中 EC 功能障碍的机制。意义目前的结果表明，额叶连接的改变可能有助于预测 TLE 患者的抑郁症。结论 我们的结果表明，额叶中减弱的θ振荡和功能连接可能是 TLE 合并抑郁症中 EC 功能障碍的机制。意义目前的结果表明，额叶连接的改变可能有助于预测 TLE 患者的抑郁症。结论 我们的结果表明，额叶中减弱的θ振荡和功能连接可能是 TLE 合并抑郁症中 EC 功能障碍的机制。意义目前的结果表明，额叶连接的改变可能有助于预测 TLE 患者的抑郁症。