OBJECTIVE To determine how long it takes for neural impulses to travel along peripheral nerve fibers in living humans. METHODS A collision test was performed to measure the conduction velocity distribution of the ulnar nerve. Two stimuli at the distal and proximal sites were used to produce the collision. Compound muscle or nerve action potentials were recorded to perform the measurements on the motor or mixed nerve, respectively. Interstimulus interval was set at 1-5 ms. A quadri-pulse technique was used to measure the refractory period and calibrate the conduction time. RESULTS Compound muscle action potential produced by the proximal stimulation started to emerge at the interstimulus interval of about 1.5 ms and increased with the increment in interstimulus interval. Two groups of motor nerve fibers with different conduction velocities were identified. The mixed nerve showed a wider conduction velocity distribution with identification of more subgroups of nerve fibers than the motor nerve. CONCLUSIONS The conduction velocity distributions in high resolution on a peripheral motor and mixed nerve are different and this can be measured with the collision test. SIGNIFICANCE We provided ground truth data to verify the neuroimaging pipelines for the measurements of latency connectome in the peripheral nervous system.

中文翻译：

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使用神经生理学技术测量周围神经的传导速度分布

目的 确定神经冲动沿周围神经纤维在活人体内传播需要多长时间。方法采用碰撞试验测量尺神经传导速度分布。远端和近端部位的两个刺激用于产生碰撞。记录复合肌肉或神经动作电位以分别对运动神经或混合神经进行测量。刺激间隔设置为 1-5 毫秒。四脉冲技术用于测量不应期和校准传导时间。结果近端刺激产生的复合肌肉动作电位在1.5ms左右的刺激间隔开始出现，并随着刺激间隔的增加而增加。确定了两组具有不同传导速度的运动神经纤维。与运动神经相比，混合神经显示出更宽的传导速度分布，识别出更多的神经纤维亚群。结论外周运动神经和混合神经的高分辨率传导速度分布是不同的，这可以通过碰撞试验来测量。意义我们提供了地面实况数据来验证用于测量周围神经系统中延迟连接组的神经影像管道。结论外周运动神经和混合神经的高分辨率传导速度分布是不同的，这可以通过碰撞试验来测量。意义我们提供了地面实况数据来验证用于测量周围神经系统中延迟连接组的神经影像管道。结论外周运动神经和混合神经的高分辨率传导速度分布是不同的，这可以通过碰撞试验来测量。意义我们提供了地面实况数据来验证用于测量周围神经系统中延迟连接组的神经影像管道。