Inflammation in the central nervous system (CNS) has been linked to demyelination and remyelination. Using zebrafish and mouse models of demyelination and remyelination, Cunha et al. now describe a novel role for myeloid differentiation factor 88 (MyD88) signaling in supporting remyelination by promoting myeloid cell-mediated inflammatory responses via TNF-α, which are essential for phagocytic myelin debris clearance and for oligodendrogenesis.

中文翻译：

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髓鞘再生促进炎症：MyD88 信号在小胶质细胞/巨噬细胞中的新作用

中枢神经系统 (CNS) 的炎症与脱髓鞘和髓鞘再生有关。Cunha 等人使用斑马鱼和小鼠脱髓鞘和髓鞘再生模型。现在描述髓样分化因子 88 (MyD88) 信号传导通过 TNF-α 促进髓样细胞介导的炎症反应来支持髓鞘再生的新作用，TNF-α 对于吞噬髓鞘碎片清除和少突胶质细胞生成至关重要。