Background

Quality of life (QOL) is an important patient-related outcome (PRO) in patients with cystic fibrosis (CF). There are several QOL questionnaires like the “Cystic Fibrosis Questionnaire Revised” (CFQ-R) or the “St George's Respiratory Questionnaire” (SGRQ) that are well validated in CF. The aim of the study was to evaluate whether the easily applicable “COPD assessment test” (CAT) can be used in CF patients.

Methods

42 CF patients were recruited within the PulmoHOM study, a prospective, observational cohort study. The CAT, the SGRQ and the CFQ-R were handed out to the patients. The spearman's rank correlation coefficient and the Cronbach's α coefficient were used for the statistical analysis.

Results

The internal consistencies of the CAT, SGRQ and the CFQ-R were high (Cronbach's α coefficients = 0.89, 0.91 and 0.83). There were significant correlations between the CAT and the total score of the SGRQ (r = 0.851, p < 0.01), between the CAT and many items of the CFQ-R (physical score of the CFQ-R and total score of the CAT: r = −0.872, p < 0.01) and between the SGRQ and the CFQ-R (physical score of the CFQ-R and total score of the SGRQ: r = −0.878, p < 0.01).

Conclusion

The main finding was the high correlation between the CAT and the validated questionnaires in CF. The CAT is a PRO instrument that can be filled quickly and that correlates well with the CFQ-R. The CAT or similar tools might be applicable in the care of CF patients.

中文翻译：

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通过COPD评估测试（CAT）轻松测量囊性纤维化患者健康相关的生活质量-一项初步研究。

背景

囊性纤维化（CF）患者的生活质量（QOL）是重要的患者相关结局（PRO）。有一些QOL问卷，例如“修订的囊性纤维化问卷”（CFQ-R）或“圣乔治呼吸问卷”（SGRQ），在CF中得到了很好的验证。该研究的目的是评估是否可以在CF患者中使用易于使用的“ COPD评估测试”（CAT）。

方法

PulmoHOM研究（一项前瞻性观察性队列研究）招募了42位CF患者。CAT，SGRQ和CFQ-R已分发给患者。使用Spearman等级相关系数和Cronbachα系数进行统计分析。

结果

CAT，SGRQ和CFQ-R的内部一致性很高（Cronbach'sα系数= 0.89、0.91和0.83）。CAT与SGRQ的总分之间存在显着相关性（r = 0.851，p <0.01），CAT与CFQ-R的许多项目之间（CFQ-R的物理分数与CAT总分之间存在显着相关性： r = -0.872，p <0.01），并且介于SGRQ和CFQ-R之间（CFQ-R的物理评分与SGRQ的总评分：r = -0.878，p <0.01）。

结论

主要发现是CAT与CF中经过验证的问卷之间的高度相关性。CAT是一种PRO仪器，可以快速填充，并且与CFQ-R紧密相关。CAT或类似工具可能适用于CF患者的护理。