During virus infection, host toll-like receptors (TLRs) can recognize different pathogen-associated molecular patterns and trigger the innate immune response. TLR7/8 can identify the single-stranded RNA (ssRNA) of the virus. This study aimed to search ssRNA sequences recognized by TLR7/8 from the SARS-CoV-2, SARS-CoV, and MERS-CoV whole genomes by a bioinformatic technique. The immunoinformatic approach showed that the SARS-CoV-2 genome has more ssRNA fragments that could be recognized by TLR7/8 than the SARS-CoV genome. These findings suggest innate immune hyperactivation by SARS-CoV-2. This activity is possibly able to provoke a robust proinflammatory response via TLR7/8 recognition and cause acute lung injury.

在病毒感染期间，宿主通行费样受体（TLR）可以识别与病原体相关的不同分子模式并触发先天免疫应答。TLR7 / 8可以识别病毒的单链RNA（ssRNA）。这项研究旨在通过生物信息技术从SARS-CoV-2，SARS-CoV和MERS-CoV全基因组中搜索被TLR7 / 8识别的ssRNA序列。免疫信息学方法表明，SARS-CoV-2基因组比SARS-CoV基因组具有更多的可被TLR7 / 8识别的ssRNA片段。这些发现表明SARS-CoV-2具有先天免疫过度激活作用。这种活动可能能够通过TLR7 / 8识别引起强烈的促炎反应，并引起急性肺损伤。