CancerEnD is an integrated resource developed for annotating 8524 unique expressed enhancers, associated genes, somatic mutations and copy number variations of 8063 cancer samples from 18 cancer types of TCGA. Somatic mutation data was taken from the COSMIC repository. To delineate the relationship of change in copy number of enhancer elements with the prognosis of cancer patients, survival analysis was done using the survival package in R. We identified 1762 overall survival associated enhancers, which can be used for prognostic purposes of cancer patients in a tissue-specific manner. CancerEnD (https://webs.iiitd.edu.in/raghava/cancerend/) is developed on a user-friendly responsive template, that enables searching, browsing and downloading of the annotated enhancer elements in terms of gene expression, copy number variation and survival association. We hope it provides a promising avenue for researchers to facilitate the understanding of enhancer deregulation in tumorigenesis, and to identify new biomarkers for therapy and disease-diagnosis.

中文翻译：

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CancerEnD：癌症相关增强子的数据库。

CancerEnD 是一个综合资源，用于注释来自 18 种癌症类型的 TCGA 的 8063 个癌症样本的 8524 个独特表达的增强子、相关基因、体细胞突变和拷贝数变异。体细胞突变数据取自 COSMIC 存储库。为了描绘增强子元件拷贝数变化与癌症患者预后的关系，使用 R 中的生存包进行生存分析。我们确定了 1762 个与总体生存相关的增强子，可用于癌症患者的预后目的组织特异性方式。CancerEnD (https://webs.iiitd.edu.in/raghava/cancerend/) 是在一个用户友好的响应模板上开发的，它可以搜索、浏览和下载基因表达方面的注释增强子元素，拷贝数变异和存活关联。我们希望它为研究人员提供一条有前途的途径，以促进对肿瘤发生中增强子失调的理解，并确定用于治疗和疾病诊断的新生物标志物。