This review summarizes existing research on the gut microbiome composition and function in psoriasis and psoriatic arthritis, exploring potential roles in disease pathogenesis, progression, and management. A strong relationship between skin, joint, and gastrointestinal inflammation exists, as demonstrated by an increased prevalence of psoriasis, psoriatic arthritis, and inflammatory bowel disease co-occurring together; however, the link between them has not been fully elucidated. Studies analyzing the gut microbiome in psoriasis and psoriatic arthritis reveal a unique pattern of dysbiosis. With regard to the gut microbiome's role in psoriasis and psoriatic arthritis pathogenesis, we discuss several theories including intestinal permeability, altered immune homeostasis, and imbalance of short- and medium-chain fatty acid-producing bacteria. We also discuss how the gut microbiome affects patient risk of psoriatic arthritis and other serious comorbidities, and how fecal microbes could be used clinically as therapeutic targets or markers of disease.

中文翻译：

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牛皮癣和银屑病关节炎的肠道微生物组。

这篇综述总结了有关牛皮癣和银屑病关节炎中肠道微生物组组成和功能的现有研究，探讨了在疾病发病机理，进展和管理中的潜在作用。皮肤，关节和胃肠道炎症之间存在密切的关系，如银屑病，银屑病关节炎和炎症性肠病并发的患病率上升所证明。但是，它们之间的联系尚未完全阐明。分析银屑病和银屑病关节炎中肠道微生物组的研究显示出独特的营养不良模式。关于肠道微生物组在牛皮癣和银屑病关节炎发病机理中的作用，我们讨论了几种理论，包括肠通透性，免疫稳态改变，短链和中链脂肪酸产生细菌的失衡。