Abstract Background/Purpose The fractions were tested to investigate their chemical composition and antifungal potential in vitro. Methods/Results The results obtained through the chromatographic analysis allowed the identification of 28 compounds. Microbiological assays were carried out in order to determine the IC50, cell viability curve and inhibitory effect of the association of the fractions with Fluconazole (FCZ), against Candida spp. through the microdilution methodology. The assays for verification of change in morphology and Minimal Fungicidal Concentration were performed in solid media. The IC50 of the isolated and associated fractions were calculated to be between 5.10 and 926.56 μg/mL, when associated with FCZ the concentrations were reduced to 512 μg/mL and 1024 μg/mL, the IC50 value of the fractions associated with fluconazole varied between 1.38 and 925.56 μg/mL. Conclusions The fractions affect the morphological transition and have a relevant antifungal potential, as they caused fungal inhibition in isolated use and potentiated the action of FCZ.

中文翻译：

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UPLC-MS-ESI-QTOF 分析和 Psidium guajava L 级分的抗念珠菌活性。

摘要 背景/目的 测试馏分以研究其化学成分和体外抗真菌潜力。方法/结果 通过色谱分析获得的结果可以鉴定 28 种化合物。进行微生物测定以确定IC50、细胞活力曲线和各组分与氟康唑(FCZ)结合对念珠菌属的抑制作用。通过微量稀释方法。在固体培养基中进行形态学变化和最小杀真菌剂浓度的验证测定。计算出的分离和相关部分的 IC50 在 5.10 和 926.56 μg/mL 之间，当与 FCZ 相关时，浓度降低到 512 μg/mL 和 1024 μg/mL，与氟康唑相关的馏分的 IC50 值在 1.38 和 925.56 μg/mL 之间变化。结论 这些馏分影响形态转变并具有相关的抗真菌潜力，因为它们在单独使用时会抑制真菌并增强 FCZ 的作用。