Objective

The objective of this study was to review the scientific articles on the use of nociceptive threshold testing (NTT) in cats and to summarize the clinical and experimental applications in this species.

Databases used

Pertinent literature was searched with PubMed, Scopus, Web of Science, Universitätsbibliothek Basel (swissbib Basel Bern) and Google Scholar. The search was then refined manually based first on article titles and abstracts, and subsequently on full texts.

Conclusions

Of the four classical acute nociceptive models used for NTT, thermal and mechanical are most commonly used in cats. Thermal stimulation is applicable in experimental settings and has been used in pharmacodynamics studies assessing feline antinociception. Although mechanical stimulation is currently less used in cats, in the future it might play a role in the evaluation of clinical feline pain. However, the low response reliability after stimulus repetition within a narrow time interval represents a major limitation for the clinical use of mechanical thresholds in this species. Challenges remain when thermal thresholds are used to investigate analgesics that have the potential to affect skin temperature, such as opioids and α2-adrenergic agonists, and when a model of inflammatory pain is reproduced in experimental cats with the purpose of evaluating non-steroidal anti-inflammatory drugs as analgesics.

中文翻译：

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在实验和临床环境中对猫使用伤害性阈值测试：定性评价。

客观的

本研究的目的是回顾有关在猫中使用伤害性阈值测试 (NTT) 的科学文章，并总结该物种的临床和实验应用。

使用的数据库

通过 PubMed、Scopus、Web of Science、Universitätsbibliothek Basel (swissbib Basel Bern) 和 Google Scholar 检索了相关文献。然后首先根据文章标题和摘要手动优化搜索，然后根据全文进行搜索。

结论

在用于 NTT 的四种经典急性伤害感受模型中，热和机械最常用于猫。热刺激适用于实验环境，并已用于评估猫镇痛的药效学研究。尽管目前在猫身上使用的机械刺激较少，但将来它可能会在评估临床猫科动物疼痛中发挥作用。然而，在狭窄的时间间隔内重复刺激后的低响应可靠性代表了该物种临床使用机械阈值的主要限制。当使用热阈值来研究可能影响皮肤温度的镇痛剂时，挑战仍然存在，例如阿片类药物和 α2-肾上腺素能激动剂，