Mutations underpin the processes in life, be it beneficial or detrimental. While mutations are assumed to be random in the bereft of selection pressures, the genetic code has underlying computable probabilities in amino acid phenotypic changes. With a wide range of implications including drug resistance, understanding amino acid changes is important. In this study, we calculated the probabilities of substitutions mutations in the genetic code leading to the 20 amino acids and stop codons. Our calculations reveal an enigmatic in-built self-preserving organization of the genetic code that averts disruptive changes at the physicochemical properties level. These changes include changes to start, aromatic, negative charged amino acids and stop codons. Our findings thus reveal a statistical mechanism governing the relationship between amino acids and the universal genetic code.

无论是有益的还是有害的，突变都是生活过程的基础。尽管假定选择压力的突变是随机的，但遗传密码在氨基酸表型变化中具有潜在的可计算概率。具有广泛的意义，包括耐药性，了解氨基酸的变化非常重要。在这项研究中，我们计算了导致20个氨基酸和终止密码子的遗传密码中替代突变的概率。我们的计算揭示了遗传密码的一个神秘的内置自我保存组织，该组织在物理化学性质水平上避免了破坏性变化。这些变化包括起始，芳香，带负电荷的氨基酸和终止密码子的变化。