Physiologically based pharmacokinetic (PBPK) models for chemicals in food animals are a useful tool in estimating chemical tissue residues and withdrawal intervals. Physiological parameters such as organ weights and blood flows are an important component of a PBPK model. The objective of this study was to compile PBPK‐related physiological parameter data in food animals, including cattle and swine. Comprehensive literature searches were performed in PubMed, Google Scholar, ScienceDirect, and ProQuest. Relevant literature was reviewed and tables of relevant parameters such as relative organ weights (% of body weight) and relative blood flows (% of cardiac output) were compiled for different production classes of cattle and swine. The mean and standard deviation of each parameter were calculated to characterize their variability and uncertainty and to allow investigators to conduct population PBPK analysis via Monte Carlo simulations. Regression equations using weight or age were created for parameters having sufficient data. These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal‐derived food safety assessment. This work also provides a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys.

中文翻译：

---

产食动物中基于生理学的药代动力学模型的生理学参数值。第一部分：牛和猪。

食用动物体内化学药品的基于生理学的药代动力学（PBPK）模型是估算化学组织残留量和停药间隔的有用工具。生理参数（例如器官重量和血流量）是PBPK模型的重要组成部分。这项研究的目的是收集包括牛和猪在内的食用动物的PBPK相关生理参数数据。在PubMed，Google Scholar，ScienceDirect和ProQuest中进行了全面的文献检索。查阅了相关文献，并针对不同生产类别的牛和猪，编制了相关参数表，例如相对器官重量（占体重的百分比）和相对血流量（占心输出量的百分比）。计算每个参数的平均值和标准差，以表征其变异性和不确定性，并允许研究人员通过蒙特卡洛模拟进行人口PBPK分析。对于具有足够数据的参数，创建了使用权重或年龄的回归方程。这些汇总的数据提供了一个全面的生理参数数据库，用于开发牛和​​猪中的PBPK化学模型，以支持动物源食品安全评估。这项工作还为汇编其他食用动物物种（包括山羊，绵羊，鸡和火鸡）的数据提供了基础。这些汇总的数据提供了一个全面的生理参数数据库，用于开发牛和​​猪中的PBPK化学模型，以支持动物源食品安全评估。这项工作还为汇编其他食用动物物种（包括山羊，绵羊，鸡和火鸡）的数据提供了基础。这些汇总的数据提供了一个全面的生理参数数据库，用于开发牛和​​猪中的PBPK化学模型，以支持动物源食品安全评估。这项工作还为汇编其他食用动物物种（包括山羊，绵羊，鸡和火鸡）的数据提供了基础。