当前位置: X-MOL 学术J. Vet. Pharmacol. Thera. › 论文详情
Comparison of the pharmacokinetics of tilmicosin in plasma and lung tissue in healthy chickens and chickens experimentally infected with Mycoplasma gallisepticum
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.473 ) Pub Date : 2020-03-04 , DOI: 10.1111/jvp.12847
Nan Zhang; Zhenxian Liu; Yanzhe Wei; Chuanzhen Zhang; Chunxiao Mao; Qinren Cai; Xiangguang Shen; Huanzhong Ding

The objectives of this study were to compare the plasma and lung tissue pharmacokinetics of tilmicosin in healthy and Mycoplasma gallisepticum‐infected chickens. Tilmicosin was orally administered at 4, 7.5 and 10 mg/kg body weight (b.w) for the infected and 7.5 mg/kg b.w for the uninfected control group. We found no significant differences in plasma tilmicosin pharmacokinetics between diseased and healthy control chickens. In contrast, the lung tissues in M. gallisepticum‐infected chickens displayed a t 1/2 (elimination half‐life) 1.76 times longer than for healthy chickens. The C max (the maximum concentration of drug in samples) of tilmicosin in M. gallisepticum‐infected chickens was lower than for controls at 7.5 mg/kg b.w (p  < .05), and the AUCinf (the area under the concentration–time curve from time 0 extrapolated to infinity) in infected chickens was higher than for the healthy chickens (p  < .05). The mean residence time of tilmicosin in infected chickens was also higher than the healthy chickens. These results indicated that the lungs of healthy chickens had greater absorption of tilmicosin than the infected chickens, and the rate of elimination of tilmicosin from infected lungs was slower.
更新日期:2020-03-04

 

全部期刊列表>>
AI核心技术
10years
材料学研究精选
Springer Nature Live 产业与创新线上学术论坛
胸腔和胸部成像专题
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
杨超勇
周一歌
华东师范大学
段炼
清华大学
廖矿标
李远
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
福州大学
南京大学
王杰
左智伟
电子显微学
何凤
洛杉矶分校
吴杰
赵延川
试剂库存
天合科研
down
wechat
bug