The objectives of this study were to compare the plasma and lung tissue pharmacokinetics of tilmicosin in healthy and Mycoplasma gallisepticum‐infected chickens. Tilmicosin was orally administered at 4, 7.5 and 10 mg/kg body weight (b.w) for the infected and 7.5 mg/kg b.w for the uninfected control group. We found no significant differences in plasma tilmicosin pharmacokinetics between diseased and healthy control chickens. In contrast, the lung tissues in M. gallisepticum‐infected chickens displayed a t _1/2 (elimination half‐life) 1.76 times longer than for healthy chickens. The C _max (the maximum concentration of drug in samples) of tilmicosin in M. gallisepticum‐infected chickens was lower than for controls at 7.5 mg/kg b.w (p  < .05), and the AUC_inf (the area under the concentration–time curve from time 0 extrapolated to infinity) in infected chickens was higher than for the healthy chickens (p  < .05). The mean residence time of tilmicosin in infected chickens was also higher than the healthy chickens. These results indicated that the lungs of healthy chickens had greater absorption of tilmicosin than the infected chickens, and the rate of elimination of tilmicosin from infected lungs was slower.

中文翻译：

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在健康鸡和实验感染鸡毒支原体的鸡中，替米考星在血浆和肺组织中的药代动力学比较。

本研究的目的是比较健康和感染鸡支原体的鸡中替米考星的血浆和肺组织药代动力学。替米考星口服剂量分别为感染者4、7.5和10 mg / kg体重（bw），未感染对照组为7.5 mg / kg bw。我们发现患病和健康对照鸡的血浆替米考星药代动力学没有显着差异。相反，感染鸡毒支原体的鸡的肺组织的t _1/2（消除半衰期）比健康鸡长1.76倍。鸡毒支原体中替米考星的C _max（样品中的最大药物浓度）在7.5 mg / kg bw时，被感染的鸡低于对照组（p  <.05），并且被感染的鸡的AUC _inf（从时间0推断到无穷大的浓度-时间曲线下的面积）高于健康鸡鸡（p  <.05）。替米考星在被感染鸡中的平均停留时间也高于健康鸡。这些结果表明，健康鸡的肺比受感染的鸡具有更高的替米考星吸收，并且从受感染的肺中清除替米考星的速度较慢。