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CncC/Maf-mediated xenobiotic response pathway in insects.
Archives of Insect Biochemistry and Physiology ( IF 1.5 ) Pub Date : 2020-04-12 , DOI: 10.1002/arch.21674 Subba Reddy Palli 1
Archives of Insect Biochemistry and Physiology ( IF 1.5 ) Pub Date : 2020-04-12 , DOI: 10.1002/arch.21674 Subba Reddy Palli 1
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Insects have evolved resistance to almost all insecticides developed for their control. Multiple mechanisms of resistance, including enhanced metabolism and excretion of insecticides, target‐site insensitivity, reduced penetration of insecticides, and avoidance behavior, have been reported. The genes coding for proteins involved in resistance have been identified in numerous insects. The enzymes and transporters required for all three phases of insecticide metabolism and excretion including cytochrome P450 monooxygenases, glutathione S‐transferases, UDP‐glucuronosyltransferases, carboxylesterases, and ATP‐binding cassette transmembrane transporters have been identified. Recent research in multiple insect species identified CNC‐bZIP transcription factor superfamily members as regulators of genes coding for enzymes and transporters involved in insecticide metabolic resistance. The information on the pathway including reactive oxygen species, cap “n” collar isoform‐C, and its heterodimer partner, muscle aponeurosis fibromatosis transcription factors involved in overexpression of enzymes and transporters involved insecticide resistance will be summarized.
中文翻译：
昆虫中 CncC/Maf 介导的异生素反应途径。
昆虫已经进化出对几乎所有为控制它们而开发的杀虫剂的抗性。已经报道了多种抗性机制，包括增强的代谢和杀虫剂的排泄、目标位点不敏感、杀虫剂渗透减少和回避行为。已经在许多昆虫中鉴定出编码与抗性有关的蛋白质的基因。杀虫剂代谢和排泄的所有三个阶段所需的酶和转运蛋白，包括细胞色素 P450 单加氧酶、谷胱甘肽 S-转移酶、UDP-葡糖醛酸转移酶、羧酸酯酶和 ATP 结合盒跨膜转运蛋白已被鉴定。最近对多种昆虫物种的研究发现，CNC-bZIP 转录因子超家族成员是编码参与杀虫剂代谢抗性的酶和转运蛋白基因的调节因子。将总结有关途径的信息，包括活性氧、帽“n”环异构体-C 及其异二聚体伙伴、参与酶过表达的肌肉腱膜纤维瘤病转录因子和涉及杀虫剂抗性的转运蛋白。
更新日期：2020-04-12
中文翻译：
昆虫中 CncC/Maf 介导的异生素反应途径。
昆虫已经进化出对几乎所有为控制它们而开发的杀虫剂的抗性。已经报道了多种抗性机制，包括增强的代谢和杀虫剂的排泄、目标位点不敏感、杀虫剂渗透减少和回避行为。已经在许多昆虫中鉴定出编码与抗性有关的蛋白质的基因。杀虫剂代谢和排泄的所有三个阶段所需的酶和转运蛋白，包括细胞色素 P450 单加氧酶、谷胱甘肽 S-转移酶、UDP-葡糖醛酸转移酶、羧酸酯酶和 ATP 结合盒跨膜转运蛋白已被鉴定。最近对多种昆虫物种的研究发现，CNC-bZIP 转录因子超家族成员是编码参与杀虫剂代谢抗性的酶和转运蛋白基因的调节因子。将总结有关途径的信息，包括活性氧、帽“n”环异构体-C 及其异二聚体伙伴、参与酶过表达的肌肉腱膜纤维瘤病转录因子和涉及杀虫剂抗性的转运蛋白。
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