A genetic variant of pri‐miR‐182 may impact the risk for the onset of multiple sclerosis in the Iranian population,American Journal of Human Biology

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A genetic variant of pri‐miR‐182 may impact the risk for the onset of multiple sclerosis in the Iranian population
American Journal of Human Biology ( IF 1.6 ) Pub Date : 2020-03-25 , DOI: 10.1002/ajhb.23415
Nadia Najafi ₁ , Maryam Peymani ₁

Affiliation

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system affecting young adults. SNPs can be used as genetic biomarkers to identify disease‐related genes such as MS. Moreover, SNPs can be considered as important determinants for an increased risk of autoimmune diseases such as MS. Studies have shown that miR‐182 is of importance in Treg cell development and function as critical regulators in autoimmune disease. So far, no study has been conducted to investigate the association between rs4541843 polymorphism in pri‐miR‐182 and MS. In the present study, we assessed the frequency of rs4541843 different alleles and genotypes and their association with MS risk in Iranian population.

中文翻译：

pri-miR-182的遗传变异可能会影响伊朗人群多发性硬化症发作的风险

多发性硬化症（MS）是影响年轻人的最常见的中枢神经系统自身免疫性疾病。SNP可用作遗传生物标记，以鉴定与疾病相关的基因，例如MS。此外，SNPs被认为是增加自身免疫性疾病（如MS）风险的重要决定因素。研究表明，miR-182在Treg细胞发育中很重要，并在自身免疫性疾病中起着至关重要的调节作用。到目前为止，尚未进行研究以研究pri-miR-182中rs4541843多态性与MS之间的关联。在本研究中，我们评估了rs4541843不同等位基因和基因型的频率以及它们与伊朗人群MS风险的关系。

更新日期：2020-03-25

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