The Alzheimer's disease (AD) research landscape is dominated by efforts to predict and prevent the condition. In clinical practice, it is difficult to establish normal aging from pathological cognitive deterioration and “imaginaries of deterioration” tied to “loss of self” take on a material form and impact assessment and diagnostic practice. Drawing on qualitative data gathered across a memory service in the UK, this paper captures practitioners’ reflections on the utility and potential impact of prediction and earlier detection. Practitioners maintain that this biological framing may reinforce uncertainties associated with sociocultural depictions of the condition and reify normative values concerning cognition and age; provoking questions concerning what kinds of values are produced by, and aligned with, bioscientific agendas. Overall, there emerges a paradox entangled in biologically redefining AD: purported precision and prediction on the one hand and increasing uncertainty on the other entwined with sociocultural imaginings of a future with AD.

中文翻译：

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生物学和“存在”的标记：退化的想象和阿尔茨海默病的生物学重新定义

阿尔茨海默病 (AD) 研究领域的主要内容是预测和预防该病。在临床实践中，很难从病理性认知退化和与“自我丧失”相关的“退化想象”的物质形式和影响评估和诊断实践中建立正常衰老。本文利用在英国的记忆服务中收集的定性数据，捕捉了从业者对预测和早期检测的效用和潜在影响的反思。从业者坚持认为，这种生物学框架可能会加强与社会文化描述相关的不确定性，并使有关认知和年龄的规范价值观具体化；引发关于生物科学议程产生并与生物科学议程一致的价值类型的问题。全面的，