Abstract A 2 × 3 factorial experiment was conducted to investigate the effects of silymarin-nanohydrogle (0, 500 free; 500 nano) and a mycotoxin (0; 2.2 mg/kg), silymarin contaminated diet on productive performance and certain serum biochemical parameters using 72 Japanese quail chicks in days 7–35 of age. Six experimental treatments consisting inclusion of 0 or 2.2 mg/kg aflatoxins in a basal diet fed to the birds receiving 0 or 500 mg/L silymarin in two free- or nanohydrogle forms via drinking water. Daily weight gain (DWG) and European production index (EPI) reduced by 6.7% and 13.6% while feed intake (FI) and FCR increased by 3.76% and 12% in the birds fed on the diet containing 2.2 mg/kg aflatoxin, respectively (p < .05). Administration of silymarin-nanohydrogle through drinking water improved FI and DWG by 3.7% and 8.1%, respectively (p < .05). Mean serum alkaline phosphatase (ALP) activity elevated by 26.1% and serum concentration of total protein (TP), glucose (GLU) and high density lipoproteins (HDL) declined by 14.4%, 6.1% and 27.1% in the birds fed on the aflatoxin-contaminated diet, respectively (p < .05). Mean serum concentration of BUN (86.4%) and GLU (12.0%) increased and Ca (10.3%) decreased in birds receiving 500 mg/kg silymarin-nanohydrogle (p < .05). The birds receiving silymarin-nanohydrogle in drinking water showed lesser liver and spleen percentage (p < .05). It was concluded that inclusion of 500 mg/kg silymarin-nanohydrogle in drinking water could significantly compensate the impaired growth performance and alter hepatic function in Japanese quails fed on a diet contaminating 2.2 mg aflatoxins. Highlights Feeding diets contaminated with 2.2 mg aflatoxins/kg suppressed growth performance and impaired hepatic function in Japanese quails. Inclusion of 500 mg/kg silymarin-nanohydrogle in drinking water alleviated the adverse impact of aflatoxins on broilers’ performance and partially improved liver function. Greater levels of silymarin-nanohydrogle may relive the aflatoxin-caused intimidating alterations in liver and blood parameters in Japanese quails.

中文翻译：

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水飞蓟素-纳米水凝胶复合物降低日本鹌鹑黄曲霉毒素毒性的功效

摘要 进行了 2 × 3 析因实验以研究水飞蓟素-纳米水凝胶（0、500 游离；500 纳米）和真菌毒素（0；2.2 毫克/千克）、水飞蓟素污染的饮食对生产性能和某些血清生化参数的影响。 72 只日本鹌鹑雏鸡 7-35 天。六种实验处理包括在基础日粮中加入 0 或 2.2 mg/kg 黄曲霉毒素，喂给鸡只通过饮用水接受 0 或 500 mg/L 水飞蓟素两种游离形式或纳米形式的水飞蓟素。日增重 (DWG) 和欧洲生产指数 (EPI) 分别降低了 6.7% 和 13.6%，而饲喂含有 2.2 mg/kg 黄曲霉毒素的日粮的鸡只的采食量 (FI) 和 FCR 分别增加了 3.76% 和 12% (p < .05)。通过饮用水施用水飞蓟素-纳米水凝胶将 FI 和 DWG 提高了 3.7% 和 8.1%，分别 (p < .05)。饲喂黄曲霉毒素的鸡群的平均血清碱性磷酸酶 (ALP) 活性提高了 26.1%，血清总蛋白 (TP)、葡萄糖 (GLU) 和高密度脂蛋白 (HDL) 浓度分别下降了 14.4%、6.1% 和 27.1% - 分别受污染的饮食 (p < .05)。在接受 500 mg/kg 水飞蓟素-纳米水凝胶的鸟类中，BUN (86.4%) 和 GLU (12.0%) 的平均血清浓度增加，Ca (10.3%) 减少 (p < .05)。在饮用水中接受水飞蓟素-纳米水凝胶的家禽表现出较低的肝脏和脾脏百分比（p < .05）。结论是，在饮用水中加入 500 mg/kg 水飞蓟素纳米水凝胶可以显着补偿以 2.2 mg 黄曲霉毒素污染为饲料的日本鹌鹑的生长性能受损并改变其肝功能。亮点 饲喂被 2.2 毫克黄曲霉毒素/公斤污染的日粮抑制了日本鹌鹑的生长性能和肝功能受损。在饮用水中加入 500 mg/kg 水飞蓟素-纳米水凝胶可减轻黄曲霉毒素对肉鸡生产性能的不利影响，并部分改善肝功能。更高水平的水飞蓟素-纳米水凝胶可能会重温黄曲霉毒素引起的日本鹌鹑肝脏和血液参数的可怕变化。