ABSTRACT This study was carried out to compare the analgesic effects and haematobiochemical changes produced by the administration of lidocaine, detomidine and lidocaine–detomidine combination in the epidural space of goats. All goats were assigned to all of the three different epidural treatments using a balanced crossover design with two-weeks washout period. Nociception was investigated by pinprick; times to the onset and duration of anti-nociception in the perineal region were demonstrated. Incoordination, ataxia and analgesic effects were carefully observed and recorded according to the scoring system. The blood samples for haematological and biochemical changes were collected at 0, 30, 60, 90 and 120 min post-treatment. Our results showed that detomidine treatment produced a highly significant (P < 0.01) and (P < 0.0001) earlier onset time than lidocaine and lidocaine–detomidine combination, respectively. Detomidine treatment had a significantly longer duration of analgesia than lidocaine (P < 0.01) and lidocaine–detomidine combination (P < 0.0001) treatments. Moreover, all treatments showed no effect on haematological or biochemical parameters, with no obvious systemic effects. In conclusion, administering a detomidine provided a longer duration of analgesia and a useful level of systemic sedation in goats.

中文翻译：

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利多卡因、地托咪定和利多卡因-地托咪定腰骶注射山羊：抗伤害作用和血液生化参数的变化

摘要 本研究旨在比较利多卡因、地托咪定和利多卡因-地托咪定组合在山羊硬膜外腔中的镇痛作用和血液生化变化。所有山羊都被分配到所有三种不同的硬膜外治疗，使用平衡交叉设计和两周的冲洗期。pinprick 对伤害感受进行了调查；证明了会阴区抗伤害感受的起效时间和持续时间。根据评分系统仔细观察和记录不协调、共济失调和镇痛作用。在治疗后 0、30、60、90 和 120 分钟收集血液学和生化变化的血液样本。我们的结果表明，地托咪定处理产生了非常显着的（P < 0.01）和（P < 0. 0001) 分别比利多卡因和利多卡因-地托咪定组合更早的起效时间。地托咪定治疗的镇痛持续时间明显长于利多卡因 (P < 0.01) 和利多卡因-地托咪定联合治疗 (P < 0.0001)。此外，所有治疗对血液学或生化参数均无影响，无明显全身效应。总之，给予地托咪定在山羊中提供了更长的镇痛持续时间和有用的全身镇静水平。无明显全身效应。总之，给予地托咪定在山羊中提供了更长的镇痛持续时间和有用的全身镇静水平。无明显全身效应。总之，给予地托咪定在山羊中提供了更长的镇痛持续时间和有用的全身镇静水平。