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The marked decrease in cardiac MIBG-uptake correlates with the severity of sleep disturbance in patients with Parkinson’s disease
Sleep and Biological Rhythms ( IF 1.0 ) Pub Date : 2020-01-23 , DOI: 10.1007/s41105-020-00253-1
Satoshi Tada , Masahiro Nomoto , Yuki Yamanishi , Noriyuki Miyaue , Rina Ando , Hayato Yabe , Masahiro Nagai

We investigated the relationship between sleep disturbances and 123 I-meta-iodobenzylguanidine (MIBG)-uptake during myocardial scintigraphy in patients with Parkinson’s disease (PD). We studied consecutive PD patients who underwent MIBG scintigraphy at our institution. Collected data included Hoehn and Yahr (HY) stage, the heart/mediastinum (H/M) ratio of MIBG scintigraphy, Epworth Sleepiness Scale score, PD Sleep Scale (PDSS)-2 score (total PDSS-2 score and its three subscales: motor problems at night, PD symptoms at night, and disturbed sleep), levodopa daily dose, total levodopa-equivalent daily dose (LEDD), and LEDD of dopamine agonists. We determined the specific binding ratio (SBR) in patients who underwent DaTSPECT to examine the relationship between each sleep disturbance scale and SPECT changes and the other evaluated items. We examined 31 patients with PD. There was a significant negative correlation between the H/M ratio and the score for disturbed sleep. The more the decreased the cardiac MIBG uptake, the higher the score for disturbed sleep ( p = 0.040). There was no correlation between the H/M ratio and other sleep scales. The HY stage correlated with the score for PD symptoms at night ( p = 0.0244), but not with other sleep scales. Twenty-one patients were evaluated by DaTSPECT; there was no correlation between SBR and any other scores used to evaluate sleep disturbances. The score for disturbed sleep on the PDSS-2 is mainly related insomnia symptoms. Thus, MIBG myocardial scintigraphy detects the severity of sleep disturbance in PD patients.

中文翻译:

帕金森病患者心脏 MIBG 摄取的显着降低与睡眠障碍的严重程度相关

我们研究了帕金森病 (PD) 患者心肌闪烁扫描期间睡眠障碍与 123 I-间碘苄基胍 (MIBG) 摄取之间的关系。我们研究了在我们机构接受 MIBG 闪烁扫描的连续 PD 患者。收集的数据包括 Hoehn 和 Yahr (HY) 分期、MIBG 闪烁扫描的心脏/纵隔 (H/M) 比率、Epworth 嗜睡量表评分、PD 睡眠量表 (PDSS)-2 评分(总 PDSS-2 评分及其三个子量表:夜间运动问题、夜间 PD 症状和睡眠障碍)、左旋多巴日剂量、左旋多巴等效日总剂量 (LEDD) 和多巴胺激动剂的 LEDD。我们确定了接受 DaTSPECT 的患者的特异性结合率 (SBR),以检查每个睡眠障碍量表与 SPECT 变化和其他评估项目之间的关系。我们检查了 31 名 PD 患者。H/M 比值与睡眠障碍评分之间存在显着负相关。心脏 MIBG 摄取减少得越多,睡眠障碍的得分越高 (p = 0.040)。H/M 比值与其他睡眠量表之间没有相关性。HY 分期与夜间 PD 症状评分相关(p = 0.0244),但与其他睡眠量表无关。DaTSPECT 评估了 21 名患者;SBR 与用于评估睡眠障碍的任何其他分数之间没有相关性。PDSS-2 睡眠障碍评分主要与失眠症状相关。因此,MIBG 心肌闪烁扫描可检测 PD 患者睡眠障碍的严重程度。心脏 MIBG 摄取减少得越多,睡眠障碍的得分越高 (p = 0.040)。H/M 比值与其他睡眠量表之间没有相关性。HY 分期与夜间 PD 症状评分相关(p = 0.0244),但与其他睡眠量表无关。DaTSPECT 评估了 21 名患者;SBR 与用于评估睡眠障碍的任何其他分数之间没有相关性。PDSS-2 睡眠障碍评分主要与失眠症状相关。因此,MIBG 心肌闪烁扫描可检测 PD 患者睡眠障碍的严重程度。心脏 MIBG 摄取减少得越多,睡眠障碍的得分越高 (p = 0.040)。H/M 比值与其他睡眠量表之间没有相关性。HY 分期与夜间 PD 症状评分相关(p = 0.0244),但与其他睡眠量表无关。DaTSPECT 评估了 21 名患者;SBR 与用于评估睡眠障碍的任何其他分数之间没有相关性。PDSS-2 睡眠障碍评分主要与失眠症状相关。因此,MIBG 心肌闪烁扫描可检测 PD 患者睡眠障碍的严重程度。但不适用于其他睡眠量表。DaTSPECT 评估了 21 名患者;SBR 与用于评估睡眠障碍的任何其他分数之间没有相关性。PDSS-2 睡眠障碍评分主要与失眠症状相关。因此,MIBG 心肌闪烁扫描可检测 PD 患者睡眠障碍的严重程度。但不适用于其他睡眠量表。DaTSPECT 评估了 21 名患者;SBR 与用于评估睡眠障碍的任何其他分数之间没有相关性。PDSS-2 睡眠障碍评分主要与失眠症状相关。因此,MIBG 心肌闪烁扫描可检测 PD 患者睡眠障碍的严重程度。
更新日期:2020-01-23
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