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Restless legs syndrome and arterial stiffness in pre-dialysis chronic kidney disease
Sleep and Biological Rhythms ( IF 1.0 ) Pub Date : 2020-03-31 , DOI: 10.1007/s41105-020-00268-8
Ibrahım Guney , Zeynep Biyik , Vedat Gencer , Yacuz Sultan Selim Akgül

Despite plenty of restless legs syndrome (RLS) studies conducted with hemodialysis patients, it has been scarcely studied in patients with predialysis chronic kidney disease (CKD). In the present study, we aimed to investigate the frequency of RLS in patients with nondialysis chronic kidney disease and explore the relationship between RLS with sleep quality, depression, pulse wave velocity (PWV), and clinical parameters. This cross-sectional study included 259 stage 3–5 predialysis CKD patients. The diagnosis of RLS was defined according to the diagnostic criteria defined by the international RLS study group. Beck depression inventory (BDI) was employed to assess depression while Pittsburgh Sleep Quality Index (PSQI) was employed to assess sleep quality. 41 patients (16%) were diagnosed with RLS. BDI and PSQI scores of patients with RLS were significantly higher than those without RLS ( p = 0.01, p = 0.03, respectively). Pulse wave velocity (PWV) was significantly lower in patients with RLS (8.0 ± 1.8) than those without RLS (8.6 ± 1.9) ( p = 0.05). Decrease in PWV and increase in BDI score demonstrated by multivariate analysis were shown as independent predictors of RLS development (ExpB = 1.266, p = 0.02 and ExpB = 0.957, p = 0.007 and p = 0.04, respectively). RLS is a significant problem in predialysis CKD patients and depression, and poor sleep quality is typical in these patients. Arterial stiffness is lower in these patients and any factors related to the pathophysiology of RLS might play important roles in modulating atherosclerosis.

中文翻译:

透析前慢性肾脏病的不宁腿综合征和动脉僵硬

尽管对血液透析患者进行了大量不宁腿综合征 (RLS) 研究,但很少在透析前慢性肾病 (CKD) 患者中进行研究。在本研究中,我们旨在调查非透析慢性肾脏病患者的 RLS 频率,并探讨 RLS 与睡眠质量、抑郁、脉搏波速度 (PWV) 和临床参数之间的关系。该横断面研究包括 259 名 3-5 期透析前 CKD 患者。RLS的诊断依据国际RLS研究组定义的诊断标准。贝克抑郁量表 (BDI) 用于评估抑郁症,而匹兹堡睡眠质量指数 (PSQI) 用于评估睡眠质量。41 名患者 (16%) 被诊断为 RLS。RLS 患者的 BDI 和 PSQI 评分显着高于无 RLS 患者(分别为 p = 0.01、p = 0.03)。RLS 患者的脉搏波速度 (PWV) (8.0 ± 1.8) 显着低于无 RLS 患者 (8.6 ± 1.9) ( p = 0.05)。多变量分析显示的 PWV 降低和 BDI 评分增加被显示为 RLS 发展的独立预测因子(分别为 ExpB = 1.266、p = 0.02 和 ExpB = 0.957、p = 0.007 和 p = 0.04)。RLS 是透析前 CKD 患者和抑郁症的一个重要问题,睡眠质量差是这些患者的典型特征。这些患者的动脉硬度较低,任何与 RLS 病理生理学相关的因素都可能在调节动脉粥样硬化中发挥重要作用。RLS 患者的脉搏波速度 (PWV) (8.0 ± 1.8) 显着低于无 RLS 患者 (8.6 ± 1.9) ( p = 0.05)。多变量分析显示的 PWV 降低和 BDI 评分增加被显示为 RLS 发展的独立预测因子(分别为 ExpB = 1.266、p = 0.02 和 ExpB = 0.957、p = 0.007 和 p = 0.04)。RLS 是透析前 CKD 患者和抑郁症的一个重要问题,睡眠质量差是这些患者的典型特征。这些患者的动脉硬度较低,任何与 RLS 病理生理学相关的因素都可能在调节动脉粥样硬化中发挥重要作用。RLS 患者的脉搏波速度 (PWV) (8.0 ± 1.8) 显着低于无 RLS 患者 (8.6 ± 1.9) ( p = 0.05)。多变量分析显示的 PWV 降低和 BDI 评分增加被显示为 RLS 发展的独立预测因子(分别为 ExpB = 1.266、p = 0.02 和 ExpB = 0.957、p = 0.007 和 p = 0.04)。RLS 是透析前 CKD 患者和抑郁症的一个重要问题,睡眠质量差是这些患者的典型特征。这些患者的动脉硬度较低,任何与 RLS 病理生理学相关的因素都可能在调节动脉粥样硬化中发挥重要作用。多变量分析显示的 PWV 降低和 BDI 评分增加被显示为 RLS 发展的独立预测因子(分别为 ExpB = 1.266、p = 0.02 和 ExpB = 0.957、p = 0.007 和 p = 0.04)。RLS 是透析前 CKD 患者和抑郁症的一个重要问题,睡眠质量差是这些患者的典型特征。这些患者的动脉硬度较低,任何与 RLS 病理生理学相关的因素都可能在调节动脉粥样硬化中发挥重要作用。多变量分析显示的 PWV 降低和 BDI 评分增加被显示为 RLS 发展的独立预测因子(分别为 ExpB = 1.266、p = 0.02 和 ExpB = 0.957、p = 0.007 和 p = 0.04)。RLS 是透析前 CKD 患者和抑郁症的一个重要问题,睡眠质量差是这些患者的典型特征。这些患者的动脉硬度较低,任何与 RLS 病理生理学相关的因素都可能在调节动脉粥样硬化中发挥重要作用。
更新日期:2020-03-31
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