Abstract

Cross-linked cationic particles 150–300 nm in diameter have been synthesized via single-stage emulsifier-free copolymerization of methyl methacrylate and 2-aminoethyl methacrylate hydrochloride in the presence of cross-linking agents (ethylene glycol dimethacrylate and N,N'-methylenebisacrylamide). Factors that enable one to control the morphology and polydispersity of the resulting particles have been determined. It has been shown that the dispersions of the particles are aggregatively stable in physiological solutions and after the sorption of biologically active molecules. The synthesized particles can be used for efficient revealing tick-borne encephalitis virus via latex agglutination reaction, with the analysis time being no longer than 10 min.

中文翻译：

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甲基丙烯酸甲酯的无乳化剂乳液共聚合作为获得阳离子颗粒的T虱脑炎病毒诊断方法

摘要

直径为150-300 nm的交联阳离子粒子是在交联剂（乙二醇二甲基丙烯酸酯和N，N'-亚甲基双丙烯酰胺）存在下通过甲基丙烯酸甲酯和甲基丙烯酸2-氨基乙酯盐酸盐的单级无乳化剂共聚反应合成的）。已经确定了能够控制所得颗粒的形态和多分散性的因素。已经表明，在生理溶液中以及在吸附生物活性分子之后，颗粒的分散体总体上是稳定的。合成的颗粒可用于通过乳胶凝集反应有效显示tick传脑炎病毒，分析时间不超过10分钟。