Abstract—

Nanosized and submicron gold particles are of great interest for application in optics, biophotonics, and analytical chemistry. In spite of the great progress that has been made in the development of methods for liquid-phase chemical synthesis of such colloids, no reliable procedures have been proposed for obtaining monodisperse particles with sizes larger than 300 nm. In this work, a method has been developed for single-stage liquid-phase synthesis of submicron gold particles via the reduction of gold ions with dopamine in the presence of poly(vinylpyrrolidone) as a stabilizer. It has been found that the sizes of the targeted particles can be varied within a range of 120–500 nm by varying poly(vinylpyrrolidone) concentration in reaction mixtures. It has been shown that colloids with the narrowest size distribution of spherical particles are obtained at poly(vinylpyrrolidone) concentrations of 0.01–1 mg/mL. The synthesized submicron particles can be used as labels in surface-enhanced Raman scattering spectroscopy and for confocal laser microscopy.

中文翻译：

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单级合成亚微米金颗粒

摘要—

纳米和亚微米级的金粒子对于光学，生物光子学和分析化学中的应用非常感兴趣。尽管在开发用于这种胶体的液相化学合成方法的方法上已经取得了巨大的进步，但是尚未提出用于获得尺寸大于300nm的单分散颗粒的可靠程序。在这项工作中，已经开发了一种方法，该方法用于通过在多乙烯基吡咯烷酮作为稳定剂的存在下用多巴胺还原金离子来单步液相合成亚微米金颗粒。已经发现，通过改变反应混合物中的聚乙烯吡咯烷酮浓度，可以在120–500 nm的范围内改变目标粒子的大小。研究表明，在聚乙烯吡咯烷酮的浓度为0.01-1 mg / mL时，可获得球形颗粒分布最窄的胶体。合成的亚微米颗粒可用作表面增强拉曼散射光谱中的标记，以及用于共聚焦激光显微镜。