Matrixins play a major role in tissue regeneration and also in various patho-physiological processes. Discovery of matrix metallo proteins (MMPs) and their detailed structural and functional analysis would lead to the development of numerous potent synthetic inhibitors of matrixins to treat certain diseases. In the present investigation, a marine cephalopod- Octopus sp. collected from Cochin, in the south western Indian Ocean was used as animal model for purification of matrixins. The measurements, count, indices and other morphometric characters were noted down before assessing the presence of matrixins in the crude extract of Octopus samples. Purification of matrixins was carried out employing gel filtration chromatography and the purified matrixins was confirmed by gelatin zymogram. The purity of the protein was checked by both native and SDS-PAGE. The studies have provided clear indications of production of MMPs or matrixins with gelatinolytic activity in Octopus sp.

中文翻译：

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从海洋头足类动物体内纯化基质胶。

基质胶在组织再生以及各种病理生理过程中起主要作用。基质金属蛋白（MMP）的发现及其详细的结构和功能分析将导致开发出许多有效的基质素合成抑制剂来治疗某些疾病。在目前的调查中，一个海洋头足类动物章鱼sp。从印度洋西南部的科钦（Cochin）收集的动物用作纯化基质蛋白的动物模型。在评估章鱼粗提物中存在基质毒素之前，记下测量，计数，指标和其他形态特征样品。使用凝胶过滤色谱法进行基质素的纯化，并通过明胶酶谱图确认纯化的基质素。通过天然和SDS-PAGE检查蛋白质的纯度。该研究提供了生产MMP或matrixins的明显迹象，在溶明胶活性八达SP 。