Purpose

Conventional and novel drug delivery systems encompass therapeutic effects for treatment and management of various conditions like cancer, diabetes, and Alzheimer’s disease but mostly show side or adverse effects. To overcome such undesirable effects, new approaches like functionalized polymers, biocarriers, drug-free particles, and metallic nanocomposite display potential applications in healthcare. Presently, nanosponges emerge as a promising carrier in various fields like agriculture, textile, fire engineering, drug delivery, and sterilization.

Methods

β-Cyclodextrin cross-linked nanosponges are porous, biocompatible, biomimetic, and therapeutic carrier for enhancing solubility, bioavailability, and stability and offering desirable pharmacokinetic profiles. Among these diversified applications of nanosponges, still, there is a lack of research interest on Gram-positive and Gram-negative microorganisms. Such drug-free nanosponges will act as an alternative to avoid or reduce toxic effects and resistance to therapeutics. So, the objective of the present study was to investigate the antimicrobial action of β-cyclodextrin-based nanosponges prepared by polymer condensation and interfacial phenomenon methods on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Candida albicans, and Clostridia perfringens.

Results

β-Cyclodextrin cross-linked nanosponges showed spherical structure with a particle size range of 100–600 nm with 0.1–0.5 of polydispersity index (PdI). The antimicrobial studies indicated that the formulations were effective against various microorganisms like E. coli > P. aeruginosa > S. aureus > S. typhi > C. albicans > Clostridia.

Conclusions

Thus, carbonyldiimidazole cross-linked β-cyclodextrin-based nanosponges showed antimicrobial activity and will emerge as an antimicrobial agent in the form of drug-free therapy against various microbes in the near future.

中文翻译：

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无药环糊精基纳米海绵具有抗菌活性。

目的

常规的和新颖的药物递送系统涵盖了用于治疗和控制各种疾病（例如癌症，糖尿病和阿尔茨海默氏病）的治疗效果，但大多数都显示出副作用或不良反应。为了克服这种不良影响，功能化聚合物，生物载体，无毒颗粒和金属纳米复合材料等新方法在医疗保健领域显示出潜在的应用。目前，纳米海绵在农业，纺织，消防工程，药物输送和消毒等各个领域中成为有希望的载体。

方法

β-环糊精交联的纳米海绵是多孔的，生物相容的，仿生的和治疗性载体，可增强溶解性，生物利用度和稳定性，并提供理想的药代动力学特征。在纳米海绵的这些多样化应用中，仍然缺乏对革兰氏阳性和革兰氏阴性微生物的研究兴趣。这种无药物的纳米海绵将作为替代品，以避免或减少毒性作用和对治疗剂的抵抗力。因此，本研究的目的是研究通过聚合物缩合和界面现象方法制备的基于β-环糊精的纳米海绵对大肠杆菌，金黄色葡萄球菌，铜绿假单胞菌，伤寒沙门氏菌的抗菌作用。，白色念珠菌和产气荚膜梭菌。

结果

β-环糊精交联的纳米海绵显示球形结构，粒径范围为100-600 nm，多分散指数（PdI）为0.1-0.5。抗菌研究表明，该制剂对多种微生物有效，如大肠杆菌>铜绿假单胞菌>金黄色葡萄球菌>伤寒杆菌>白色念珠菌>梭状芽胞杆菌。

结论

因此，羰基二咪唑交联的基于β-环糊精的纳米海绵具有抗菌活性，并且将在不久的将来以无药治疗的形式作为抗微生物剂出现。