Purpose

The purpose of this study was to present the novel MRI findings of palatine gland lesion-associated IgG4-related disease (PGL-IgG4-RD) and to compare the imaging features with those in normal individuals.

Materials and methods

We retrospectively evaluated the MRI scans of 12 patients with PGL-IgG4-RD and 12 control individuals. We measured the thickness of the palatal regions and calculated the T2-weighted signal intensity ratio of palatal regions to cerebral white matter (HWR) and compared them between the PGL-IgG4-RD and control groups.

Results

In univariate analysis, the HWR of the palatal regions on T2-weighted imaging was smaller in the PGL-IgG4-RD group than in the control group (average = 1.2 vs. 1.9, p < 0.001). The palate thickness in patients with PGL-IgG4-RD was significantly greater than that in controls (average = 12 vs 6 mm, p < 0.001). The cut-off value of the between-group palate thickness on coronal MRI was 8 mm.

Conclusion

The thickening of the palatal regions seen with low signal intensity on T2-weighted imaging may be a characteristic imaging feature of PGL-IgG4-RD. Such findings will be useful for the timely diagnosis and subsequent treatment planning of IgG4-RDHP.

中文翻译：

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腭腺病变相关 IgG4 相关疾病的 MR 成像：一项初步研究。

目的

本研究的目的是展示腭腺病变相关 IgG4 相关疾病 (PGL-IgG4-RD) 的新 MRI 发现，并将其成像特征与正常个体的成像特征进行比较。

材料和方法

我们回顾性评估了 12 名 PGL-IgG4-RD 患者和 12 名对照个体的 MRI 扫描结果。我们测量了腭区的厚度并计算了腭区与脑白质 (HWR) 的 T2 加权信号强度比，并在 PGL-IgG4-RD 和对照组之间进行了比较。

结果

在单变量分析中，PGL-IgG4-RD 组的 T2 加权成像上腭区域的 HWR 小于对照组（平均值 = 1.2 vs. 1.9，p  < 0.001）。PGL-IgG4-RD 患者的上颚厚度显着大于对照组（平均 = 12 对 6 毫米，p  < 0.001）。冠状 MRI 上组间腭厚度的临界值为 8 毫米。

结论

在 T2 加权成像上以低信号强度看到的腭区增厚可能是 PGL-IgG4-RD 的特征性成像特征。这些发现将有助于 IgG4-RDHP 的及时诊断和后续治疗计划。