In this study, a drying method was developed for effective removal of residual solvents from toluene- or methyl tertiary butyl ether-induced amorphous paclitaxel. By simple rotary evaporation with alcohol pretreatment, there was sufficient removal of the residual toluene, methyl tertiary butyl ether, methanol, and ethanol concentrations of paclitaxel to bring them below the ICH-specified values (890, 5000, 3,000, and 5,000 ppm). In addition, SEM analysis and ultrasonic treatment revealed that residual solvent removal was associated with the formation of pores on the surface of the sample because of the high vapor pressure of the toluene-alcohol mixture or the methyl tertiary butyl ether-alcohol mixture and hydrogen bonding between the solvent and the alcohol.

在这项研究中，开发了一种干燥方法，用于从甲苯或甲基叔丁基醚诱导的非晶紫杉醇中有效去除残留溶剂。通过简单的旋转蒸发和酒精预处理，紫杉醇的残留甲苯，甲基叔丁基醚，甲醇和乙醇浓度得到了足够的去除，使其低于ICH规定的值（890、5000、3,000和5,000 ppm）。此外，SEM分析和超声处理表明，残留溶剂的去除与样品表面上孔的形成有关，这是由于甲苯-醇混合物或甲基叔丁基醚-醇混合物的高蒸气压和氢键在溶剂和酒精之间。