Objective: This study assessed the feasibility to restore finger-specific sensory feedback in transradial amputees with electrical stimulation of evoked tactile sensation (ETS). Methods: Here we investigated primary somatosensory cortical (SI) responses of ETS using Magnetoencephalography. Results: SI activations revealed a causal correlation with peripheral stimulation of projected finger regions on the stump skin. Peak latency was accountable to neural transmission from periphery to SI. Peak intensity of SI response was proportional to the strength of peripheral stimulation, manifesting a direct neural pathway from skin receptors to SI neurons. Active regions in SI at the amputated side were consistent to the finger/hand map of homunculus, forming a mirror imaging to that of the contralateral hand. With sensory feedback, amputees can recognize a pressure at prosthetic fingers as that at the homonymous lost fingers. Conclusions: Results confirmed that the direct neural pathway from periphery to SI allows effective communication of finger-specific sensory information to these amputees.

中文翻译：

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通过非侵入性诱发触觉恢复经桡骨截肢者的手指特异性感觉反馈

客观的：本研究评估了通过诱发触觉 (ETS) 电刺激恢复经桡骨截肢者手指特异性感觉反馈的可行性。方法：在这里，我们使用脑磁图研究了 ETS 的初级体感皮层 (SI) 反应。结果：SI 激活揭示了与残端皮肤上投影手指区域的外围刺激存在因果关系。峰值延迟对从外围到 SI 的神经传输负责。SI 反应的峰值强度与外周刺激的强度成正比，表明从皮肤受体到 SI 神经元的直接神经通路。截肢侧 SI 中的活动区域与 homunculus 的手指/手图一致，与对侧手的图像形成镜像。通过感官反馈，截肢者可以识别假肢手指的压力，就像失去同义手指的压力一样。结论：结果证实，从外围到 SI 的直接神经通路允许将手指特异性感觉信息有效地传达给这些截肢者。