Abstract Background Morinda morindoides has been used as herbal medicine in Africa for a long time. It possesses potential therapeutic activities such as antiplasmodial, antispermatogenic, anti-bacterial, anti-fungal, anti-diarrheal effects, stomach pain and constipation reliefs. However, there has been no literature summarising its potential effects. This study therefore aims to systematically review the therapeutic activities of this medicinal plant as well as its pharmacological activities. Materials and methods Nine databases were selected to search suitable articles namely MEDLINE (PubMed), ISI, Scopus, Google Scholar, Global Health Library (GHL), Virtual Health Library (VHL), POPLINE, New York Academy of Medicine gray Literature Report (NYAM), and System for Information on gray Literature in Europe (SIGLE). Based on inclusion and exclusion criteria, we included 54 papers for the systemic review. Results Briefly, in vitro studies showed that M. morindoides possessed anti-malarial, anti-bacterial, anti-fungal, anti-amoebic, anti-larval, spasmolytic, anti-oxidant effects and complementary modulation. Moreover, those effects were emphasized in animal studies. The plant also showed positive activities on body metabolism studied on animal models such as hypotensive, hypoglycemic, hypolipidemic actions. M. morindoides showed its safety on animals’ organs as it did not dramatically change in blood parameters or injure cardiac tissues. However, there were many inconsistent results from various studies in terms of its benefits while its extracts showed a wide range of safety on different cells. Conclusion M. morindoides has proven to have potential therapeutic effects in vitro and in vivo models. Therefore, higher quality studies on human are necessary to be conducted, which can provide stronger evidence to confirm M. morindoides’s effects.

中文翻译：

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巴戟天：对其治疗活性的系统评价

摘要 背景 巴戟天在非洲被用作草药已有很长时间了。它具有潜在的治疗活性，例如抗疟原虫、抗精子生成、抗菌、抗真菌、抗腹泻、缓解胃痛和便秘。然而，没有文献总结其潜在影响。因此，本研究旨在系统地审查这种药用植物的治疗活性及其药理活性。材料与方法 选取九个数据库检索合适的文章，即 MEDLINE (PubMed)、ISI、Scopus、Google Scholar、全球健康图书馆 (GHL)、虚拟健康图书馆 (VHL)、POPLINE、纽约医学会灰色文献报告 (NYAM) ) 和欧洲灰色文献信息系统 (SIGLE)。根据纳入和排除标准，我们纳入了 54 篇论文进行系统评价。结果 简而言之，体外研究表明，M.morindoides 具有抗疟疾、抗菌、抗真菌、抗阿米巴、抗幼虫、解痉、抗氧化作用和互补调节作用。此外，动物研究强调了这些影响。该植物还显示出对动物模型研究的身体代谢的积极活动，例如降血压、降血糖、降血脂作用。M. morindoides 显示其对动物器官的安全性，因为它不会显着改变血液参数或损伤心脏组织。然而，就其益处而言，各种研究有许多不一致的结果，而其提取物对不同细胞显示出广泛的安全性。结论 M。morindoides 已被证明在体外和体内模型中具有潜在的治疗作用。因此，有必要对人类进行更高质量的研究，这可以为证实 M. morindoides 的作用提供更有力的证据。