Mass spectrometry (MS) is an effective tool for the structural analysis of oligonucleotides. Currently, various modifications of oligonucleotides have been proposed to increase the efficacy and safety of oligonucleotide therapeutics. For MS‐based structural characterization, the fragmentation behavior of modified oligonucleotides by MS must first be determined.

中文翻译：

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与碰撞诱导的解离碎片相比，寡核苷酸结构差异对基质辅助的激光解吸/电离源内衰减的影响。

质谱（MS）是寡核苷酸结构分析的有效工具。当前，已提出寡核苷酸的各种修饰以增加寡核苷酸治疗剂的功效和安全性。对于基于MS的结构表征，必须首先确定MS修饰的寡核苷酸的片段化行为。