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Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-29 , DOI: 10.1111/jfbc.13213 Arshad Mehmood 1 , Liang Zhao 1 , Muhammad Ishaq 1 , Muhammad Usman 1 , Oumeddour Dounya Zad 1 , Imam Hossain 1 , Rifat Nowshin Raka 1 , Muhammad Naveed 1 , Lei Zhao 1 , Chengtao Wang 1 , Muhammad Nadeem 2
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-29 , DOI: 10.1111/jfbc.13213 Arshad Mehmood 1 , Liang Zhao 1 , Muhammad Ishaq 1 , Muhammad Usman 1 , Oumeddour Dounya Zad 1 , Imam Hossain 1 , Rifat Nowshin Raka 1 , Muhammad Naveed 1 , Lei Zhao 1 , Chengtao Wang 1 , Muhammad Nadeem 2
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The aim of this study was to examine the preventive action of grapefruit juice (GFJ) against potassium oxonate‐induced hyperuricemic mice. The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL‐1β, caspase‐1, NLRP3, and ASC. Furthermore, histopathology analysis revealed that GFJ markedly improve the renal and intestinal morphology. The mRNA expression of urate transporter 1, glucose transporter 9 were downregulated, whereas ATP‐binding cassette transporter (ABCG2) was upregulated in the GFJ‐treated group. The results of immunohistochemistry revealed that the ABCG2 protein expression in the small and large intestine was significantly upregulated after the GFJ administration. These results suggested that GFJ can be used as a urate lowering agent and future mechanistic studies should be conducted.
中文翻译：
葡萄柚汁对草酸钾诱导的高尿酸血症小鼠的止尿和尿酸排尿作用。
这项研究的目的是检验葡萄柚汁（GFJ）对草酸钾诱导的高尿酸血症小鼠的预防作用。结果表明，GFJ显着（p <.05）抑制血清和肝黄嘌呤氧化酶，降低尿酸水平，血清肌酐，尿调节蛋白和血尿素氮水平至正常和较低的炎症相关基因IL-1β，caspase-1，NLRP3和ASC。此外，组织病理学分析表明，GFJ显着改善了肾脏和肠道的形态。GFJ处理组的尿酸盐转运蛋白1，葡萄糖转运蛋白9的mRNA表达下调，而ATP结合盒转运蛋白（ABCG2）的表达上调。免疫组织化学的结果显示，在施用GFJ后，小肠和大肠中ABCG2蛋白的表达显着上调。这些结果表明GFJ可以用作尿酸盐降低剂，并且应该进行进一步的机理研究。
更新日期：2020-04-29
中文翻译：
葡萄柚汁对草酸钾诱导的高尿酸血症小鼠的止尿和尿酸排尿作用。
这项研究的目的是检验葡萄柚汁（GFJ）对草酸钾诱导的高尿酸血症小鼠的预防作用。结果表明，GFJ显着（p <.05）抑制血清和肝黄嘌呤氧化酶，降低尿酸水平，血清肌酐，尿调节蛋白和血尿素氮水平至正常和较低的炎症相关基因IL-1β，caspase-1，NLRP3和ASC。此外，组织病理学分析表明，GFJ显着改善了肾脏和肠道的形态。GFJ处理组的尿酸盐转运蛋白1，葡萄糖转运蛋白9的mRNA表达下调，而ATP结合盒转运蛋白（ABCG2）的表达上调。免疫组织化学的结果显示，在施用GFJ后，小肠和大肠中ABCG2蛋白的表达显着上调。这些结果表明GFJ可以用作尿酸盐降低剂，并且应该进行进一步的机理研究。
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