Task phase-specific involvement of the rat posterior parietal cortex in performance of the TUNL task.,Genes, Brain and Behavior

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Task phase-specific involvement of the rat posterior parietal cortex in performance of the TUNL task.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-04-29 , DOI: 10.1111/gbb.12659
Gavin A Scott ₁ , Shuang Cai ₁ , Yuanyi Song ₁ , Max C Liu ₁ , Quentin Greba ₁ , John G Howland ₁

Affiliation

The posterior parietal cortex (PPC) participates in cognitive processes including working memory (WM), sensory evidence accumulation, and perceptually guided decision making. However, surprisingly little work has used temporally precise manipulations to dissect its role in different epochs of behavior taking place over short timespans, such as WM tasks. As a result, a consistent view of the temporally precise role of the PPC in these processes has not been described. In the present study, we investigated the temporally specific role of the PPC in the Trial‐Unique, Nonmatching‐to‐Location (TUNL) task, a touchscreen‐based, visuospatial WM task that relies on the PPC. To disrupt PPC activity in a temporally precise manner, we applied mild intracranial electrical stimulation (ICES). We found that intra‐PPC ICES (100 μA) significantly impaired accuracy in TUNL without significantly altering response latency. Moreover, we found that the impairment was specific to ICES applied during the delay and test phases of TUNL. Consistent with previous reports showing delay‐ and choice‐specific neuronal activity in the PPC, the results provide evidence that the rat PPC is required for maintaining memory representations of stimuli over a delay period as well as for making successful comparisons and choices between test stimuli. In contrast, the PPC appears not to be critical for initial encoding of sample stimuli. This pattern of results may indicate that early encoding of visual stimuli is independent of the PPC or that the PPC becomes engaged only when visual stimuli are spatially complex or involve memory or decision making.

中文翻译：

大鼠后顶叶皮层在执行 TUNL 任务中的任务阶段特定参与。

后顶叶皮层 (PPC) 参与认知过程，包括工作记忆 (WM)、感官证据积累和知觉引导决策。然而，令人惊讶的是，很少有工作使用时间精确的操作来剖析其在短时间跨度内发生的不同行为时代中的作用，例如 WM 任务。因此，尚未描述 PPC 在这些过程中的时间精确作用的一致观点。在本研究中，我们调查了 PPC 在 Trial-Unique, Nonmatching-to-Location (TUNL) 任务中的时间特定作用，TUNL 任务是一种依赖于 PPC 的基于触摸屏的视觉空间 WM 任务。为了以时间精确的方式破坏 PPC 活动，我们应用了轻度颅内电刺激 (ICES)。我们发现内部 PPC ICES (100 μA) 显着降低了 TUNL 的准确性，而没有显着改变响应延迟。此外，我们发现损伤是特定于在 TUNL 的延迟和测试阶段应用的 ICES。与之前显示 PPC 中延迟和选择特定神经元活动的报告一致，结果提供证据表明，大鼠 PPC 是在延迟期间维持刺激的记忆表征以及在测试刺激之间进行成功比较和选择所必需的。相比之下，PPC 似乎对样本刺激的初始编码并不重要。这种结果模式可能表明视觉刺激的早期编码与 PPC 无关，或者 PPC 仅在视觉刺激空间复杂或涉及记忆或决策时才参与。

更新日期：2020-04-29

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