Introduction: Proper device selection is crucial for the clinical results of inhalation therapy. However, none of the available devices fully conforms to the requirements for delivering drug with increased patient adherence, and we are still looking for the ideal inhaler. For this reason, there are several ongoing technical innovations to improve inhaler devices.Areas covered: Progress in pulmonary drug delivery device technology is examined, focusing on innovations in pressurized metered dose inhalers, dry powder inhalers, nebulizers, and soft mist inhalers.Expert opinion: Both formulation improvements and new device technologies have been developed over the last couple of decades through an improved understanding of the mechanisms of aerosolization and lung deposition. Digital health is offering the potential to produce inhalers with a wider range of monitoring capabilities, but further studies are needed, in particular as regards the analysis of cost-effectiveness. Furthermore, there are still substantial issues that must be overcome in order to continually innovate and improve targeted inhaled drug delivery to the lungs. In any case, there are other potential therapeutic possibilities for COPD in development that may be administered by inhalation, whose clinical use requires advances and improvements in the devices used for administration.

中文翻译：

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用于治疗慢性阻塞性肺疾病的肺部药物输送装置的进展。

简介：正确选择设备对于吸入疗法的临床效果至关重要。但是，没有可用的设备完全符合增加患者依从性的药物输送要求，我们仍在寻找理想的吸入器。因此，有几项正在进行中的技术创新正在改进吸入器设备：涵盖的领域：研究了肺部药物输送设备技术的进展，重点是加压定量吸入器，干粉吸入器，雾化器和软雾吸入器的创新。 ：在过去的几十年中，通过对雾化和肺部沉积机理的深入了解，开发了配方改进和新设备技术。数字医疗为生产具有更广泛监控功能的吸入器提供了潜力，但是还需要进一步研究，尤其是在成本效益分析方面。此外，仍然存在必须克服的实质性问题，以便不断创新和改善向肺部的靶向吸入药物输送。在任何情况下，COPD在发展中还有其他潜在的治疗可能性，可以通过吸入给药，其临床用途需要改进和改善用于给药的装置。为了持续创新和改善向肺部的靶向吸入药物输送，仍然有许多必须克服的问题。在任何情况下，COPD在发展中还有其他潜在的治疗可能性，可以通过吸入给药，其临床用途需要改进和改善用于给药的装置。为了持续创新和改善向肺部的靶向吸入药物输送，仍然有许多必须克服的问题。在任何情况下，COPD在发展中还有其他潜在的治疗可能性，可以通过吸入给药，其临床用途需要改进和改善用于给药的装置。