CD4+Foxp3+ regulatory T (Treg) cells are key players in keeping excessive inflammation in check. Mounting evidence has shown that Treg cells exert much more diverse functions in both immunological and non-immunological processes. The development, maintenance and functional specification of Treg cells are regulated by multilayered factors, including antigens and TCR signaling, cytokines, epigenetic modifiers and transcription factors (TFs). In the review, we will focus on TFs by summarizing their unique and redundant roles in Treg cells under physiological and pathophysiological conditions. We will also discuss the recent advances of Treg trajectories between lymphoid organs and non-lymphoid tissues. This review will provide an updated view of the newly identified TFs and new functions of known TFs in Treg biology.

中文翻译：

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Treg 稳态和功能规范的转录调节。


CD4+Foxp3+ 调节性 T (Treg) 细胞是控制过度炎症的关键角色。越来越多的证据表明，Treg 细胞在免疫和非免疫过程中发挥着更加多样化的功能。 Treg 细胞的发育、维持和功能规范受到多层因素的调节，包括抗原和 TCR 信号、细胞因子、表观遗传修饰剂和转录因子 (TF)。在这篇综述中，我们将重点关注转录因子，总结它们在生理和病理生理条件下在 Treg 细胞中独特和冗余的作用。我们还将讨论淋巴器官和非淋巴组织之间 Treg 轨迹的最新进展。本次综述将提供新发现的转录因子和已知转录因子在 Treg 生物学中的新功能的最新观点。