Belonging to the category of catecholamine-based medications, isoprenaline is excessively beneficial in the heart disease management. Nevertheless, serious adverse consequences can occur following the consumption of high concentrations of this drug. The present study aimed for highly sensitivity co-detection of isoprenaline and paracetamol in aqueous solutions by designing and synthesizing a novel sensor based on feather-like La³⁺/ZnO nano-flowers and N-(ferrocenylmethylidene)fluoren-2-amine-modified carbon paste electrode (La³⁺/ZnONFMF2ACPE). To this end, the electrocatalytic oxidation of isoprenaline on the surface of La³⁺/ZnONFMF2ACPE was evaluated by varied techniques, including chronoamperometry, cyclic voltammetry and differential pulse voltammetry. A linear calibration curve was plotted for different concentrations of isoprenaline (0.1–400.0 μM) with 0.05 μM of detection limit. Finally, acceptable results were obtained after the detection of isoprenaline and paracetamol in human serum, urine and drug real samples using the produced sensor.

中文翻译：

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羽毛状的La 3+ / ZnO纳米花和N-（二茂铁基亚甲基）芴-2-胺修饰的碳糊电极在生物和制药介质中的异戊二烯和对乙酰氨基酚的共检测：新型传感器的分析

属于儿茶酚胺类药物的类别中，异丙肾上腺素对心脏病的治疗非常有益。但是，食用高浓度该药物可能会产生严重的不良后果。本研究旨在通过设计和合成基于羽毛状La ³⁺ / ZnO纳米花和N-（二茂铁基亚甲基）芴-2-胺修饰的新型传感器，以高灵敏度共检测水溶液中的异丙肾上腺素和扑热息痛。碳糊电极（La ³⁺ / ZnONFMF2ACPE）。为此，La ³⁺表面上的异戊二烯的电催化氧化/ ZnONFMF2ACPE通过多种技术进行了评估，包括计时安培法，循环伏安法和差分脉冲伏安法。绘制了不同浓度的异丙肾上腺素（0.1–400.0μM）和0.05μM检出限的线性校准曲线。最后，使用生产的传感器检测人血清，尿液和药物真实样品中的异丙肾上腺素和扑热息痛后，可获得可接受的结果。