Many animal models have been established for respiratory syncytial virus (RSV) infection of infants with the purpose of studying the pathogenesis, immunological response, and pharmaceutical testing and the objective of finding novel therapies and preventive measures. This review centers on a neonatal lamb model of RSV infection that has similarities to RSV infection of infants. It includes a comprehensive description of anatomical and immunological similarities between ovine and human lungs along with comparison of pulmonary changes and immune responses with RSV infection. These features make the newborn lamb an effective model for investigating key aspects of RSV infection in infants. The importance of RSV lamb model application in preclinical therapeutic trials and current updates on new studies with the RSV-infected neonatal lamb are also highlighted.

中文翻译：

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新生羔羊呼吸道合胞病毒（RSV）感染模型


已经建立了许多针对婴儿呼吸道合胞病毒（RSV）感染的动物模型，目的是研究其发病机制、免疫反应和药物测试，并寻找新的治疗和预防措施。本综述以 RSV 感染的新生儿羔羊模型为中心，该模型与婴儿 RSV 感染相似。它全面描述了绵羊和人肺之间的解剖学和免疫学相似性，以及 RSV 感染时肺部变化和免疫反应的比较。这些特征使新生羔羊成为研究婴儿 RSV 感染关键方面的有效模型。还强调了 RSV 羔羊模型在临床前治疗试验中应用的重要性以及 RSV 感染的新生羔羊新研究的最新进展。