Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones,Synthesis

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Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones
Synthesis ( IF 2.2 ) Pub Date : 2020-04-28 , DOI: 10.1055/s-0040-1707525
Mikhail Krasavin _{1,

2} , Dmitry Dar’in ₁ , Grigory Kantin ₁ , Olga Bakulina ₁

Affiliation

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones from sulfonyl chlorides is described. It involves the conversion of the sulfonyl chloride to sodium sulfinate, alkylation of the latter with α-haloketones followed by diazo transfer using the ‘sulfonyl-azide-free’ (‘SAFE’) protocol in aqueous medium. The simple and expedient method relies on readily available starting materials and provides facile access to a wide variety of valuable diazo reagents for organic synthesis.

中文翻译：

轻松从磺酰氯和α-卤代酮中一锅获得α-重氮-β-酮砜

描述了一种从磺酰氯制备α-重氮-β-酮砜的方便的一锅法。它包括将磺酰氯转化为亚磺酸钠，将后者用α-卤代烷烷基化，然后在水性介质中使用“无磺酰叠氮化物”（'SAFE'）方案进行重氮转移。简单方便的方法依赖于容易获得的起始原料，并且可以轻松获得用于有机合成的各种有价值的重氮试剂。

更新日期：2020-04-28

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