Oxytocin is an important modulator of human affiliative behaviors, including social skills, human pair bonding, and friendship. CD38 will be discussed as an immune marker and then in more detail the mechanisms of CD38 on releasing brain oxytocin. Mention is made of the paralogue of oxytocin, vasopressin, that has often overlapping and complementary functions with oxytocin on social behavior. Curiously, vasopressin does not require CD38 to be released from the brain. This review discusses the social salience hypothesis of oxytocin action, a novel view of how this molecule influences much of human social behaviors often in contradictory ways. The oxytocinergic-vasopressinergic systems are crucial modulators of broad aspects of human personality. Of special interest are studies of these two hormones in trust related behavior observed using behavioral economic games. This review also covers the role of oxytocin in parenting and parental attachment.

In conclusion, the effects of oxytocin on human behavior depend on the individual’s social context and importantly as well, the individual’s cultural milieu, viz. East and West.

Acronyms

ACC = Anterior Cingulate

ADP = Adenosine diphosphate

AQ = Autism Quotient

cADPR = Cyclic ADP-ribose

CNS = Central nervous system

DA = Dopamine

eQTLC = Expression Quantitative Trait Loci

LC-NE = Locus Coeruleus-Norepinephrine

MRI = Magnetic Resonance Imaging

OFC = Orbitofrontal cortices

OXT = Oxytocin

RAGE = Receptor for advanced glycation end-products

SARM1 = Sterile Alpha and toll/interleukin-1 receptor motif-containing 1

TRPM2= Transient Receptor Potential Cation Channel Subfamily M Member 2

AVP = Vasopressin

中文翻译：

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CD38 和催产素作为人类社会行为的串联分子调节剂的新作用。

催产素是人类亲和行为的重要调节剂，包括社交技能、人际关系和友谊。CD38 将作为免疫标志物进行讨论，然后更详细地讨论 CD38 释放脑催产素的机制。提到了催产素的旁系同源物加压素，它在社会行为上通常与催产素具有重叠和互补的功能。奇怪的是，加压素不需要 CD38 从大脑中释放出来。这篇综述讨论了催产素作用的社会显着性假说，这是一种关于这种分子如何经常以相互矛盾的方式影响人类社会行为的新观点。催产素-血管加压素系统是人类人格广泛方面的关键调节剂。特别感兴趣的是使用行为经济游戏观察到的信任相关行为中的这两种激素的研究。这篇综述还涵盖了催产素在养育和父母依恋中的作用。

总之，催产素对人类行为的影响取决于个人的社会背景，更重要的是，个人的文化环境，即。东和西。

首字母缩略词

ACC = 前扣带回

ADP = 腺苷二磷酸

AQ = 自闭症商数

cADPR = 环状 ADP-核糖

CNS = 中枢神经系统

DA = 多巴胺

eQTLC = 表达数量性状基因座

LC-NE = 蓝斑-去甲肾上腺素

MRI = 磁共振成像

OFC = 眶额皮质

OXT = 催产素

RAGE = 晚期糖基化终产物受体

SARM1 = 无菌 Alpha 和 toll/interleukin-1 受体基序包含 1

TRPM2= 瞬时受体电位阳离子通道亚科 M 成员 2

AVP = 加压素