It is unclear whether cerebrospinal fluid (CSF) phosphatidylcholines (PCs) are associated with neuroimaging measures of amyloid deposition and neurodegeneration (glucose metabolism, cortical thickness, and hippocampal volume), cognitive decline, or risk of mild cognitive impairment (MCI) among cognitively unimpaired older adults. This study investigated the associations of 19 individual CSF PC concentrations and their total sum with cross-sectional and longitudinal measures of amyloid deposition and neurodegeneration, global and domain-specific cognitive z-scores, and risk of MCI among 655 cognitively unimpaired participants, mean age of 71 years, enrolled in the Mayo Clinic Study of Aging. Neither the CSF total PC concentration nor individual CSF PCs were cross-sectionally or longitudinally associated with neuroimaging measures, cognition, or risk of MCI.

中文翻译：

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梅奥诊所衰老研究中脑脊液总磷脂酰胆碱、神经变性、认知能力下降和轻度认知障碍风险之间的关联


目前尚不清楚脑脊液 (CSF) 磷脂酰胆碱 (PC) 是否与淀粉样蛋白沉积和神经变性（葡萄糖代谢、皮质厚度和海马体积）、认知能力下降或认知未受损人群中轻度认知障碍 (MCI) 的神经影像学测量相关老年人。本研究调查了 655 名认知未受损参与者的 19 名个体 CSF PC 浓度及其总和与淀粉样蛋白沉积和神经变性的横断面和纵向测量、整体和特定领域认知 z 评分以及 MCI 风险之间的关联，平均年龄71 岁，参加了梅奥诊所衰老研究。脑脊液总 PC 浓度和个体脑脊液 PC 均与神经影像学测量、认知或 MCI 风险没有横向或纵向相关性。