Thymic stromal lymphopoietin (TSLP) acts on dendritic cells (DCs), which prime helper T (Th) cells to become type 2 cytokine producing cells. Recently, a different set of populations of TSLP-responsive DCs has been discovered. Here, we identified two populations of CD103loEpCAMhi migratory DCs (fraction I and fraction II) that accumulated in skin-draining lymph nodes in response to TSLP expressed in the mouse skin. Fraction I DCs with CD11b+PDL2hi expression primed naïve Th cells to differentiate into cells secreting IFN-γ, IL-17A and IL-22, while fraction II DCs with CD11bloPDL2+ expression primed naïve Th cells to differentiate into cells secreting IL-4, IL-5, IL-9, IL-13 and IL-10. Fraction I DCs migrated from the skin via IL-4Rα signaling pathway, whereas fraction II DCs migrated partially via TSLPR signaling pathway. All suggest that at least two populations of CD103loEpCAMhi DCs with distinct functions and pathways could migrate in response to TSLP expression in the skin.

中文翻译：

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响应于胸腺基质淋巴细胞生成素在皮肤中的表达，在引流皮肤的淋巴结中积累了两个树突细胞种群。

胸腺基质淋巴细胞生成素（TSLP）作用于树突状细胞（DC），该树突状辅助T（Th）细胞成为产生2型细胞因子的细胞。最近，发现了一组不同的TSLP响应DC种群。在这里，我们确定了两个CD103loEpCAMhi迁移DC种群（第I部分和第II部分），这些DC聚集在排干淋巴结中以响应小鼠皮肤中表达的TSLP。具有CD11b + PDL2hi表达的I部分DC引发初生Th细胞分化为分泌IFN-γ，IL-17A和IL-22的细胞，而具有CD11bloPDL2 +表达的II级DC引发初生Th细胞分化为分泌IL-4，IL的细胞。 -5，IL-9，IL-13和IL-10。I部分DC通过IL-4Rα信号通路从皮肤迁移，而II部分DC通过TSLPR信号通路部分迁移。