In the last twenty years an impressive body of evidence in diverse inflammatory animal disease models and human tissues, has established polyunsaturated fatty acids (PUFA) derived specialized-pro-resolving mediators (SPM), as essential mediators for controlling acute inflammation, immune responses and wound healing and for resolving acute inflammation in many non-ocular tissues. SPM pathways and receptors are highly expressed in the ocular surface where they regulate wound healing, nerve regeneration, innate immunity and sex-specific regulation of auto-immune responses. Recent evidence indicates that in the eye these resident SPM networks are important for maintaining ocular surface health and immune homeostasis. Here, we will review and discuss evidence for SPMs and other PUFA-derived mediators as important endogenous regulators and biomarkers of ocular surface health and disease and their therapeutic potential.

中文翻译：

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脂质介质网络作为眼表治疗剂和生物标志物的潜力。


在过去的二十年里，在不同的炎症动物疾病模型和人体组织中，大量的证据表明，多不饱和脂肪酸（PUFA）衍生的专门促消退介质（SPM）是控制急性炎症、免疫反应和炎症反应的重要介质。伤口愈合和解决许多非眼组织的急性炎症。 SPM 通路和受体在眼表面高度表达，调节伤口愈合、神经再生、先天免疫和自身免疫反应的性别特异性调节。最近的证据表明，在眼睛中，这些驻留的 SPM 网络对于维持眼表健康和免疫稳态非常重要。在这里，我们将回顾和讨论 SPM 和其他 PUFA 衍生介质作为眼表健康和疾病的重要内源性调节剂和生物标志物及其治疗潜力的证据。