Proliferation of endothelial cells in the choroid plexus of normal and hydrocephalic mice,Journal of Chemical Neuroanatomy

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Proliferation of endothelial cells in the choroid plexus of normal and hydrocephalic mice
Journal of Chemical Neuroanatomy ( IF 2.7 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.jchemneu.2020.101796
Ayumi Asami ₁ , Erkin Kurganov ₁ , Seiji Miyata ₁

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The choroid plexus (CP), located at the walls of the brain ventricles, produces and secretes cerebrospinal fluid (CSF). Hydrocephalus is a neurological disorder in which the CP abnormally secretes excess amounts of CSF into the ventricles. There is currently no information on the vascular dynamics of the CP in adult brains under normal and hydrocephalic conditions. In the present study, we reported the continuous proliferation of endothelial cells in the CP of normal mice, which depended on vascular endothelial cell growth factor (VEGF). The proliferation of endothelial cells increased in mice with intraventricular hemorrhage, which was attenuated by a pretreatment with the toll-like receptor 4 (TLR4) inhibitor VIPER. Moreover, the intracerebroventricular infusion of the TLR4 agonist, lipopolysaccharide, increased endothelial cell proliferation in the CP and induced ventriculomegaly. The present results provide insights into the importance of the TLR4-initiated and VEGF-dependent proliferation of endothelial cells in the pathogenesis of hydrocephalus.

中文翻译：

正常和脑积水小鼠脉络丛中内皮细胞的增殖

脉络丛 (CP) 位于脑室壁，产生和分泌脑脊液 (CSF)。脑积水是一种神经系统疾病，其中 CP 异常地将过量的 CSF 分泌到心室中。目前没有关于正常和脑积水条件下成人大脑中 CP 血管动力学的信息。在本研究中，我们报道了正常小鼠 CP 中内皮细胞的持续增殖，这取决于血管内皮细胞生长因子 (VEGF)。脑室内出血小鼠的内皮细胞增殖增加，这种情况通过 Toll 样受体 4 (TLR4) 抑制剂 VIPER 预处理减弱。此外，脑室内输注 TLR4 激动剂脂多糖，CP 中内皮细胞增殖增加并诱导脑室扩大。目前的结果提供了对 TLR4 启动和 VEGF 依赖性内皮细胞增殖在脑积水发病机制中的重要性的见解。

更新日期：2020-07-01

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