Stress urinary incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height. SUI is more frequent among post-menopausal women. In the absence of bladder contraction, vesical pressure exceeds urethral pressure leading to urine leakage. The main aim of this study is to utilize fluid-structure interaction techniques to model bladder and urethra computationally under an external pressure like sneezing. Both models have been developed with linear elastic properties for the bladder wall while the patient model has also been simulated utilizing the Mooney-Rivlin solid model. The results show a good agreement between the clinical data and the predicted values of the computational models, specifically the pressure at the center of the bladder. There is 1.3% difference between the predicted vesical pressure and the vesical pressure obtained from urodynamic tests. It can be concluded that the accuracy of the predicted pressure in the center of the bladder is significantly higher for the simulation assuming nonlinear material property (hyperelastic) for the bladder in comparison to the accuracy of the linear elastic model. The model is beneficial for exploring treatment solutions for SUI disorder. Graphical abstract 3D processing of bladder deformation during abdominal pressure of a the physiological model and b the pathological model (starting from left to right and up to down, consecutively).

中文翻译：

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压力性尿失禁中支持器官对预测膀胱压力的影响的计算分析。

压力性尿失禁（SUI）或尿液从尿道漏出是由于诸如咳嗽或跳高之类的压力导致腹压升高引起的。绝经后女性中的SUI更为常见。在没有膀胱收缩的情况下，膀胱压力超过尿道压力，导致尿液渗漏。这项研究的主要目的是利用流体-结构相互作用技术在打喷嚏等外部压力下计算膀胱和尿道模型。两种模型均已开发出具有膀胱壁线性弹性特性的模型，而患者模型也已使用Mooney-Rivlin实体模型进行了模拟。结果显示临床数据与计算模型的预测值之间有很好的一致性，特别是膀胱中心的压力。有1。预测的膀胱压力与从尿流动力学测试获得的膀胱压力之间存在3％的差异。可以得出结论，与线性弹性模型的准确性相比，在假设膀胱的非线性材料特性（超弹性）的情况下，模拟得出的膀胱中心压力的准确性要高得多。该模型有助于探索SUI障碍的治疗方案。生理模型和病理模型的腹部压力期间膀胱变形的图形抽象3D处理（从左到右，从上到下，连续）。可以得出结论，与线性弹性模型的准确性相比，在假设膀胱的非线性材料特性（超弹性）的情况下，模拟得出的膀胱中心压力的准确性要高得多。该模型有助于探索SUI障碍的治疗方案。生理模型和病理模型的腹部压力期间膀胱变形的图形抽象3D处理（从左到右，从上到下，连续）。可以得出结论，与线性弹性模型的准确性相比，在假设膀胱的非线性材料特性（超弹性）的情况下，模拟得出的膀胱中心压力的准确性要高得多。该模型有助于探索SUI障碍的治疗方案。生理模型和病理模型的腹部压力期间膀胱变形的图形抽象3D处理（从左到右，从上到下，连续）。