In this issue of Science Signaling, Temprine et al report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway-targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

中文翻译：

---

DNA聚合酶κ：是敌还是友？

在本期《科学信号》中，Temprine等人报道，病灶中转移DNA聚合酶Polκ的上调介导了针对BRAF途径靶向抑制剂的抵抗和黑色素瘤细胞的饥饿。这些结果证明了Polκ在细胞适应压力中的作用。