Background In clinical practice, there is the need to optimize imaging usage in MM patients. Accordingly, the aim of this paper was to develop a simple computed tomography (CT) scoring method for MM, able to shorten and simplify the interpretation time with good intra- and inter-reader reliability. This method, named MSBDS (Myeloma Spine and Bone Damage Score) was developed with the final aim to use standard total-body CT in the routine practice of MM centres as a complement of standard evaluations in patients undergoing stem cells transplantation. Methods We used a widely accepted consensus formation method and literature research during three structured face-to-face meetings specifically designed to combine opinions from a group of experts with proven experience in multiple myeloma care and/or musculoskeletal CT to facilitate the consensus on the field of study topics and the contents of the MSBDS score. Seven practical requisites for the MSBDS score were agreed. A total of 70 MM patients (mean age, 60 years ±9.2 [standard deviation]; range, 35–70 years) undergoing total-body CT was included to develop MSBDS scores. Patients data were already stored in the Radiological database for other Research studies IRB approved (054/2019). Readers to test the MSDMS were radiologists and clinicians involved in MM care or expert in bone damage scores with different level of experience in musculoskeletal and total body CT. Readers were blinded to the clinical data of the patients. Results The MSBDS scores based on the consensus work described above and literature analysis was finalized. MSBDS is based on an additive scale with assessment of a total body CT with the bone window one time and includes indicators of structural bone damage and instability or fracture risk. The total score is given by the sum of item scores for abnormalities detected. Its values range from 0 (minimum) to values > 10 where 10 is represented by high-risk patients. In high-risk patients immediate surgical or radiation oncologist consultation is suggested. Conclusions The MSBDS descriptive criteria are easy, highly reproducible and can be considered as a strong base for harmonizing total body CT interpretation in multiple myeloma patients undergoing stem cell transplantation.

中文翻译：

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在标准计算机断层扫描上接受干细胞移植的多发性骨髓瘤患者的简化评分系统的开发和定义：骨髓瘤脊柱和骨损伤评分 (MSBDS)

背景 在临床实践中，需要优化 MM 患者的成像使用。因此，本文的目的是为 MM 开发一种简单的计算机断层扫描 (CT) 评分方法，能够缩短和简化解释时间，并具有良好的读者内和读者间可靠性。这种名为 MSBDS（骨髓瘤脊柱和骨损伤评分）的方法的开发最终目的是在 MM 中心的常规实践中使用标准全身 CT 作为对接受干细胞移植的患者的标准评估的补充。方法 我们在三个结构化的面对面会议中使用了广泛接受的共识形成方法和文献研究，这些会议专门旨在结合一组在多发性骨髓瘤治疗和/或肌肉骨骼 CT 方面具有丰富经验的专家的意见，以促进该领域的共识研究主题和 MSBDS 分数的内容。商定了 MSBDS 分数的七个实际要求。共有 70 名接受全身 CT 的 MM 患者（平均年龄，60 岁 ±9.2 [标准差]；范围，35-70 岁）被纳入 MSBDS 评分。患者数据已存储在放射学数据库中，用于 IRB 批准的其他研究 (054/2019)。测试 MSDMS 的读者是参与 MM 护理的放射科医生和临床医生，或在肌肉骨骼和全身 CT 方面具有不同经验水平的骨损伤评分专家。读者对患者的临床数据不知情。结果 基于上述共识工作和文献分析的 MSBDS 评分最终确定。MSBDS 基于附加量表，评估一次带有骨窗的全身 CT，包括结构性骨损伤和不稳定或骨折风险的指标。总分由检测到的异常的项目分数总和给出。其值范围从 0（最小值）到值 > 10，其中 10 代表高危患者。对于高危患者，建议立即进行外科或放射肿瘤学家会诊。结论 MSBDS 描述标准很简单，