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Optical Manipulation of CRISPR/Cas9 Functions: From Ultraviolet to Near-Infrared Light
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-04-28 , DOI: 10.1021/acsmaterialslett.0c00041 Yuxuan Chen 1 , Xiaojie Yan 1 , Yuan Ping 1
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-04-28 , DOI: 10.1021/acsmaterialslett.0c00041 Yuxuan Chen 1 , Xiaojie Yan 1 , Yuan Ping 1
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Optical manipulation has been widely exploited as a noninvasive and precise means for a wide range of biomedical applications, such as controlled drug release and neuron activation. Recent efforts that have been dedicated to the optical regulation of CRISPR/Cas9 systems greatly impart spatiotemporal specificity, fast reversibility, and remote controllability to genome editing and transcriptional modulation. Herein, we summarize the recent progresses of various optical strategies for manipulating CRISPR/Cas9 systems. In particular, emerging material strategies for the near-infrared optical control of CRISPR/Cas9 functions are also highlighted. Finally, current challenges and future outlooks in this field from material perspectives are discussed.
中文翻译：
CRISPR / Cas9功能的光学操纵：从紫外线到近红外光
光学操作已被广泛地用作无创且精确的手段，用于广泛的生物医学应用，例如受控药物释放和神经元活化。致力于CRISPR / Cas9系统光学调控的最新努力极大地赋予了时空特异性，快速可逆性和对基因组编辑和转录调控的远程可控性。在此，我们总结了操纵CRISPR / Cas9系统的各种光学策略的最新进展。特别是，还着重介绍了用于CRISPR / Cas9功能近红外光学控制的新兴材料策略。最后，从物质的角度讨论了该领域的当前挑战和未来前景。
更新日期：2020-04-28
中文翻译：
CRISPR / Cas9功能的光学操纵：从紫外线到近红外光
光学操作已被广泛地用作无创且精确的手段，用于广泛的生物医学应用，例如受控药物释放和神经元活化。致力于CRISPR / Cas9系统光学调控的最新努力极大地赋予了时空特异性，快速可逆性和对基因组编辑和转录调控的远程可控性。在此，我们总结了操纵CRISPR / Cas9系统的各种光学策略的最新进展。特别是，还着重介绍了用于CRISPR / Cas9功能近红外光学控制的新兴材料策略。最后，从物质的角度讨论了该领域的当前挑战和未来前景。
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