Photo-responsive Self-Reducible Polymers: Overcoming the Spatiotemporal Barriers for Hypersensitivity,ACS Materials Letters

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Photo-responsive Self-Reducible Polymers: Overcoming the Spatiotemporal Barriers for Hypersensitivity
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-04-28 , DOI: 10.1021/acsmaterialslett.0c00070
Chuang Weng ₁ , Haodong Chen ₁ , Taoran Xu ₁ , Zifen Li ₁ , Xinfu Liu ₁ , Mingming Ding ₁ , Qin Zhang ₁ , Hong Tan ₁ , Qiang Fu ₁

Affiliation

To overcome the spatiotemporal barriers to conventional stimuli-responsive polymeric materials, we report a photo-responsive self-reducible polymer with a built-in photo-locked stimulus precursor derived from dithiothreitol. The smart polymer could hierarchically self-assemble into a layered vesicular structure in an aqueous solution, and undergo a self-cleavage of l-cystine residues in the backbone, in response to reducing moieties uncaged by ultraviolet light in the side chains. The photo-generation of stimulus in situ can potentially overcome the steric hindrance and temporal limitation, leading to a site-specific and ultrafast release of payloads for effective delivery of therapeutics. Our work provides a new approach to the development of smart responsive biodegradable polymers.

中文翻译：

光反应性自还原聚合物：克服超敏反应的时空障碍

为了克服常规刺激响应性聚合物材料的时空障碍，我们报道了一种具有自二硫苏糖醇衍生的内置光锁定刺激前体的光响应性自还原聚合物。响应于减少由侧链中的紫外线未解开的部分，智能聚合物可以在水溶液中分层自组装成分层的囊状结构，并在骨架中经历1-胱氨酸残基的自裂解。光刺激原位产生可以潜在地克服空间障碍和时间限制，从而导致有效有效地递送治疗剂的有效载荷的部位特异性和超快释放。我们的工作为开发智能响应式可生物降解聚合物提供了一种新方法。

更新日期：2020-04-28

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