Functional implications of CaMKII alternative splicing,European Journal of Neuroscience

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Functional implications of CaMKII alternative splicing
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-04-28 , DOI: 10.1111/ejn.14761
Roman Sloutsky ₁ , Margaret M Stratton ₁

Affiliation

Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) is known to be a crucial regulator in the post-synapse during long-term potentiation. This important protein has been the subject of many studies centered on understanding memory at the molecular, cellular, and organismic level. CaMKII is encoded by four genes in humans, all of which undergo alternative splicing at the RNA level, leading to an enormous diversity of expressed proteins. Advances in sequencing technologies have facilitated the discovery of many new CaMKII transcripts. To date, newly discovered CaMKII transcripts have been incorporated into an ambiguous naming scheme. Herein, we review the initial experiments leading to the discovery of CaMKII and its subsequent variants. We propose the adoption of a new, unambiguous naming scheme for CaMKII variants. Finally, we discuss biological implications for CaMKII splice variants.

中文翻译：

CaMKII 可变剪接的功能意义

钙²⁺已知/钙调蛋白依赖性蛋白激酶 II (CaMKII) 是长时程增强过程中突触后的关键调节剂。这种重要的蛋白质一直是许多研究的主题，这些研究集中在分子、细胞和有机体水平上理解记忆。CaMKII 由人类的四个基因编码，所有这些基因都在 RNA 水平上进行选择性剪接，从而导致表达蛋白的巨大多样性。测序技术的进步促进了许多新 CaMKII 转录本的发现。迄今为止，新发现的 CaMKII 转录本已被纳入一个模棱两可的命名方案中。在此，我们回顾了导致 CaMKII 及其后续变体发现的初始实验。我们建议为 CaMKII 变体采用一种新的、明确的命名方案。最后，

更新日期：2020-04-28

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